PMID: 9529928Jan 1, 1997Paper

Morphological studies of the lungs in chronic hypobaric hypoxia

Polish Journal of Pathology : Official Journal of the Polish Society of Pathologists
M Sulkowska

Abstract

The aim of the present study was to evaluate the effect of hypobaric hypoxia on the changes observed within lung parenchyma, particularly in the surfactant system-forming structures. The experiment used male Wistar rats, 180-220g b.w. The animals were kept in a hypobaric chamber for 3, 10 and 30 days. Pressure in the chamber (380mm Hg) corresponded to air rarefaction at an altitude of 5500m. Control animals were kept in the same room near the chamber at normal atmospheric pressure. The changes observed in the lungs were evaluated basing on ultrastructural analysis by transmission electron microscopy. The present results indicate phasic character of the changes occurring within lung parenchyma, including the surfactant system-forming structures. In the early phase (3 days), destructive-exudative changes predominated (delamelation of type II pneumocytes; oedematous changes, damage to the alveolar lining layer, accumulation of alveolar macrophages). In the later phases, repair-proliferative processes were predominant (increased number of type II pneumocytes, focal intensification of fibroplasia). The changes within the surfactant system-forming structures were accompanied by the accumulation of granulocytes and monocytes (hypobari...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Roczniki Akademii Medycznej W Białymstoku = Annales Academiae Medicae Bialostocensis
S Sulkowski
Polish Journal of Pathology : Official Journal of the Polish Society of Pathologists
S Sulkowski
Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
S SulkowskiB Szynaka
© 2022 Meta ULC. All rights reserved