Morphological studies on the synthesis of secretory granules in convoluted tubules of mouse submandibular gland

The Anatomical Record
M KaihoM Kumegawa

Abstract

The synthesis of zymogen-like secretory granules in convoluted tubules of mouse submandibular gland (SMG) was investigated by histometry, light microscopy and electron microscopy. In normal males secretory granules in the SMG increased greatly from 25 days after birth and reached a maximum level 50 days after birth. Castration of adult male mice markedly decreased the level, but it was completely restored by testosterone administration. A parallel was found between change in the granule level and the amount of rough endoplasmic reticulum (RER) in the convoluted tubular cells during development or after various treatments. Development of the Golgi apparatus was also observed in the cells when the granules increase. Both the increase in the granules and in the RER induced by testosterone were prevented by actinomycin D or puromycin. These results indicate that the granule contents are synthesized on the RER under the control of testosterone, and then condensed in the Golgi apparatus.

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Citations

Dec 1, 1984·Hormones and Behavior·B GrayG F Meunier
Jan 24, 1977·Biochimica Et Biophysica Acta·T TakumaM Kumegawa
Jul 1, 1977·Journal of Oral Pathology·G S SchusterD H Pashley
Feb 1, 1979·Hormones and Behavior·C Lee, D W Ingersoll
Sep 1, 1996·Differentiation; Research in Biological Diversity·Y IzutsuS Tochinai
Oct 1, 1990·Differentiation; Research in Biological Diversity·R TawaS Hirose
Jan 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Shingo KurabuchiEdward W Gresik
Oct 1, 1983·Journal of Dental Research·M M Ferguson, A M Bannon
Jan 1, 1994·Microscopy Research and Technique·E W Gresik
Jan 16, 2021·Cellular and Molecular Life Sciences : CMLS·Akiko SuzukiJunichi Iwata

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