PMID: 3754932Jun 1, 1986Paper

Morphological transformation and chromosome damage by amsacrine in C3H/10T1/2 clone 8 cells

Mutation Research
L R FergusonS Nesnow

Abstract

Morphological transformation, cell survival, chromosomal aberrations and micronuclei were measured in C3H/101/2CL8 cells after 24 h exposure to amsacrine. A weak but dose-related increase in the percentage of dishes containing transformed foci occurred. As previously reported for alkylating agents, this effect was increased by treating 5 days instead of 1 day after plating. There was no evidence for gene mutation at the Na/K ATPase locus, although amsacrine induced micronuclei in a large percentage of cells and chromosomal aberrations, including interchange events and double minute chromosomes, in dividing cells. In would appear that transformation and chromosomal events may be related in amsacrine-treated C3H/10T1/2CL8 cells. The results strongly suggest that amsacrine has carcinogenic potential, possibly related to its chromosome-breaking properties.

References

Aug 1, 1974·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B F Cain, G J Atwell

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Citations

Nov 6, 2009·Carcinogenesis·Paul L SkipperSteven R Tannenbaum
Jan 1, 1994·Environmental and Molecular Mutagenesis·L R Ferguson, B C Baguley
Sep 1, 1991·Mutation Research·L R Ferguson, W A Denny

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