Morphological transformation of early passage golden Syrian hamster embryo cells derived from cryopreserved primary cultures as a reliable in vitro bioassay for identifying diverse carcinogens

PMID: 863543May 15, 1977

Morphological transformation of early passage golden Syrian hamster embryo cells derived from cryopreserved primary cultures as a reliable in vitro bioassay for identifying diverse carcinogens

International Journal of Cancer. Journal International Du Cancer

R J PientaW B Lebherz

Abstract

Cryopreserved primary cultures of golden Syrian hamster embryo cells were used as the source of target and feeder cells for establishing an in vitro carcinogenesis bioassay. The primary culture giving the best overall response in a pretest before freezing gave positive results in 20 consecutive experiments when retested with 3-methylcholanthrene after cryopreservation, indicating that pretested cryopreserved cultures can serve as a source of susceptible target cells in an in vitro carcinogenesis bioassay. Similarly prepared and cryopreserved cultures served satisfactorily as feeder cells. Susceptible positive cultures were used to test a large number of carcinogenic and non-carcinogenic chemicals in this system. The results showed a very high positive correlation (90.8%) between morphological transformation and the reported carcinogenic activity of the chemicals. Transformation was not observed when cells were tested with a few carcinogens that may not be metabolized to their active forms by early passage hamster embryo cells. N-2-acetylaminofluorene transformed cells only when tested in the presence of hamster liver microsomes. No false positive results were obtained when non-carcinogens were bioassayed, nor was spontaneous tr...Continue Reading

References

Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection

Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·B N AmesF D Lee

Transformation of cell cultures as an indication of the carcinogenic potential of chemicals

Sep 1, 1973·Journal of the National Cancer Institute·A E FreemanR J Huebner

Evaluation of short-term tests for carcinogenicity

Aug 1, 1974·Toxicology and Applied Pharmacology·D R StoltzH C Grice

Chemical oncogenesis in culture

Jan 1, 1973·Advances in Cancer Research·C Heidelberger

Evaluation of an in vitro assay system for carcinogens based on prior infection of rodent cells with nontransforming RNA tumor virus

Apr 1, 1974·Journal of the National Cancer Institute·J S RhimJ H Weisburger

In vitro transformation of Syrian hamster embryo cells by diverse chemical carcinogens

Feb 4, 1972·Nature·J A DipaoloP J Donovan

Biologic manifestations of oncogenesis in vitro: a critique

Nov 1, 1974·Journal of the National Cancer Institute·K K Sanford

Metabolism of the carcinogenic hydrocarbon benzo(a)pyrene in human fibroblast and epithelial cells

Mar 15, 1973·International Journal of Cancer. Journal International Du Cancer·E Huberman, L SACHS

Cell susceptibility to transformation and cytotoxicity by the carcinogenic hydrocarbon benzo[a]pyrene

Oct 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·E Huberman, L SACHS

In vitro transformation of hamster cells by polycyclic hydrocarbons: factors influencing the number of cells transformed

Apr 21, 1971·Nature: New Biology·J A DipaoloR L Nelson

IN VITRO CELL TRANSFORMATION WITH CHEMICAL CARCINOGENS

Dec 21, 1963·Nature·Y BERWALD, L SACHS

Citations

Reproductive hazards of fire fighting. II. Chemical hazards

Jan 1, 1991·American Journal of Industrial Medicine·M A McDiarmidR Duffy

Evaluation of coal liquids derived from the EDS process in carcinogenesis screening tests

May 1, 1995·Journal of Applied Toxicology : JAT·R H McKeeR T Przygoda

The genetic toxicity of 1,2-dibromo-3-chloropropane, 1,2-dibromo-3-chloro-2-methylpropane, and 1,2,3-tribromo-2-methylpropane

Dec 1, 1987·Cell Biology and Toxicology·R H McKeeK A Traul

Morphological transformation and catalase activity of Syrian hamster embryo cells treated with hepatic peroxisome proliferators, TPA and nickel sulphate

Jan 1, 1990·Cell Biology and Toxicology·S O MikalsenT Sanner

An evaluation of three pesticides: piritione, supercypermethrin and metolachlor in transformation bioassays of BHK21 and hamster embryo cells

Oct 1, 1992·Cell Biology and Toxicology·D SlamenováC Oravec

Trenbolone induces micronucleus formation and neoplastic transformation in Syrian hamster embryo fibroblasts but not in mouse C3H10T1/2 cells

Aug 1, 1988·Archives of Toxicology·D SchiffmannD Henschler

Collagen gel culture system and analysis of estrogen effects on mammary carcinogenesis

Jul 1, 1984·Archives of Toxicology·S NandiM Edery

Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis. Part II

Sep 1, 1982·Digestive Diseases and Sciences·W H Bachrach, A F Hofmann

Vanadium compounds promote the induction of morphological transformation of hamster embryo cells with no effect on gap junctional cell communication

Jul 1, 1990·Cell Biology and Toxicology·E RivedalT Sanner

Effect of fetal bovine serum on 3-methylcholanthrene-induced transformation of hamster cells in vitro

Sep 1, 1979·In Vitro·R F SchumanW B Lebherz

Assessment of environmental contamination associated with a mammalian cell transformation assay

Sep 1, 1981·In Vitro·E B SansoneJ A Poiley

Establishment and characterization of a new cell line from a hereditary renal rat tumor

Jun 1, 1983·In Vitro·P EkerJ V Johannessen

Species specificity affects the choice of S9 preparations for use in the hamster embryo cell transformation system

Aug 1, 1984·In Vitro·J A Poiley, R Raineri

Effects of incubation in an atmosphere of 20% CO2 in air on the Syrian hamster embryo clonal transformation assay

Jan 1, 1985·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·R T PrzygodaA Tummey

In vitro assessment of the toxicity of metal compounds : I. Mammalian Cell transformation

Jun 1, 1982·Biological Trace Element Research·J Daniel Heck, M Costa

Changes in expression of bcl-2 and bax in Syrian hamster embryo (SHE) cells exposed to ZnCl2

Nov 20, 2004·Archives of Toxicology·M A MaireP Vasseur

Carcinogenic potency of perfluorooctane sulfonate (PFOS) on Syrian hamster embryo (SHE) cells

Nov 8, 2011·Archives of Toxicology·N JacquetP Vasseur

Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry

Nov 16, 2011·Odontology·Morio KobayashiTakeki Tsutsui

Perfluorooctanoic acid (PFOA) acts as a tumor promoter on Syrian hamster embryo (SHE) cells

Jul 26, 2012·Environmental Science and Pollution Research International·N JacquetP Vasseur

Effects of hepatic peroxisome proliferators and 12-O-tetradecanoyl phorbol-13-acetate on catalase and other enzyme activities of embryonic cells in vitro

Feb 1, 1990·Biochemical Pharmacology·S O MikalsenT Sanner

Characterization of microbial metabolites of sulfolithocholic acid by high-performance liquid chromatography

Feb 1, 1981·Journal of Steroid Biochemistry·M I KelseyB Shaikh

Ploidy dependence of induced mutation frequency in transformed Syrian hamster cells

Apr 1, 1980·Mutation Research·D W Morry, P O Ts'o

Activation of phenanthrene to mutagenic metabolites and evidence for at least two different activation pathways

Mar 1, 1981·Mutation Research·F OeschH R Glatt

Hamster hepatocyte-mediated activation of procarcinogens to mutagens in the L5178Y/TK mutation assay

Dec 1, 1982·Mutation Research·D E Amacher, S C Paillet

Induction of selective DNA amplification and morphological cell transformation in Syrian hamster embryo cells

Oct 1, 1990·Mutation Research·P KleinJ R Schlehofer

Recommended protocols based on a survey of current practice in genotoxicity testing laboratories: III. Cell transformation in C3H/10T1/2 mouse embryo cell, BALB/c 3T3 mouse fibroblast and Syrian hamster embryo cell cultures

Feb 1, 1991·Mutation Research·V C DunkelE R Nestmann

Expression dynamics of transforming phenotypes in X-irradiated Syrian golden hamster embryo cells

Jul 1, 1991·Mutation Research·M Watanabe, K Suzuki

The genotoxicity of lead

Jan 1, 1993·Mutation Research·C Winder, T Bonin

Comparison of the standard and reduced pH Syrian hamster embryo (SHE) cell in vitro transformation assays in predicting the carcinogenic potential of chemicals

Sep 21, 1996·Mutation Research·R J IsfortR LeBoeuf

A comprehensive protocol for conducting the Syrian hamster embryo cell transformation assay at pH 6.70

Sep 21, 1996·Mutation Research·G A KerckaertR LeBoeuf

The pH 6.7 Syrian hamster embryo cell transformation assay for assessing the carcinogenic potential of chemicals

Sep 21, 1996·Mutation Research·R LeBoeufR J Isfort

The induction and control of radiogenic transformation in vitro: cellular and molecular mechanisms

Jan 1, 1985·Pharmacology & Therapeutics·C Borek

Metal carcinogenesis: mechanistic implications

Jan 1, 1992·Pharmacology & Therapeutics·E T Snow

Short-term tests for carcinogens and mutagens

Sep 1, 1979·Mutation Research·M HollsteinW W Nichols

A review of the genotoxicity of food, drug and cosmetic colours and other azo, triphenylmethane and xanthene dyes

Mar 1, 1982·Mutation Research·R D Combes, R B Haveland-Smith

Mutagenicity, carcinogenicity and teratogenicity of beryllium

Jul 1, 1987·Mutation Research·A Léonard, R Lauwerys

Genetic toxicity of 2-acetylaminofluorene, 2-aminofluorene and some of their metabolites and model metabolites

Oct 1, 1994·Mutation Research·R H Heflich, R E Neft

Mutagenicity of phenanthrene and phenanthrene K-region derivatives

Apr 1, 1979·Mutation Research·M BückerF Oesch

The metabolism of N-acetyl-2-aminofluorene to a mutagen in L5178Y/TK+/-mouse lymphoma cells

Aug 1, 1981·Mutation Research·D E AmacherJ A Elliott

Mutagenicity tests and in vitro transformation assays on triethanolamine

Jun 1, 1982·Mutation Research·K InoueY Tanaka

Locus specificity of mutagenicity of 2,4-diaminotoluene in both L5178Y mouse lymphoma and AT3-2 Chinese hamster ovary cells

Feb 1, 1984·Mutation Research·W J CoppingerE D Thompson

A study of the potential genotoxicity of methapyrilene and related antihistamines using the hepatocyte/DNA repair assay

Feb 1, 1984·Mutation Research·J D BudroeD A Casciano

The genotoxicity of a variety of aniline derivatives in a DNA repair test with primary cultured rat hepatocytes

Oct 1, 1988·Mutation Research·N YoshimiH Shimizu

Clastogenicity evaluation of seven chemicals commonly found at hazardous industrial waste sites

Dec 1, 1989·Mutation Research·S S SandhuX D Zhou

An interlaboratory comparison of enhanced morphological transformation of Syrian hamster embryo cells cultured under conditions of reduced bicarbonate concentration and pH

Mar 1, 1989·Mutation Research·R LeBoeufR Raineri

Genetic toxicity of six carcinogens and six non-carcinogens in the Drosophila wing spot test

Nov 1, 1990·Mutation Research·N K TripathyH Frei

Assessment of toxicity, clastogenicity, mutagenicity and transforming activity of pentoxifylline in mammalian cells cultured in vitro

Oct 1, 1994·Mutation Research·D SlamenováE Szabová

Balbc/3T3 cell transformation response to extracts of organic air samples as seen by their survival in aggregate form

Oct 1, 1985·Mutation Research·J T ZelikoffT J Kneip

Mouse strain differences in the induction of micronuclei by polycyclic aromatic hydrocarbons

Nov 1, 1987·Mutation Research·S SatoN Inui

Screening for carcinogens by the DNA synthesis inhibition test using human fibroblasts

Jan 1, 1987·Mutation Research·K YanagisawaS Gotoh

Genotoxicity and cell transformation studies with sorbates in Syrian hamster embryo fibroblasts

Aug 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D Schiffmann, J Schlatter

Liver medium-term bioassay in rats for screening of carcinogens and modifying factors in hepatocarcinogenesis

Nov 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R Hasegawa, N Ito

Transforming activity of selected polycyclic aromatic hydrocarbons and their nitro-derivatives in BALB/3T3 A31-1-1 cells

Jul 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C W SheuP P Fu

Formation of hemoglobin-benzo[a]pyrene adducts in human erythrocytes incubated with benzo[a]pyrene and hamster embryo cells

Dec 17, 1990·Toxicology·D A Haugen, I S Zegar

Role of plasma fibronectin in the morphological transformation of hamster embryo cells

Oct 1, 1982·Cancer Letters·E Rivedal

Induction of morphological transformation and unscheduled DNA synthesis in Syrian hamster embryo fibroblasts by hexachlorobutadiene and its putative metabolite pentachlorobutenoic acid

Jul 1, 1984·Cancer Letters·D SchiffmannD Henschler

Transformation of BHK 21/CL 13 cells by various polycyclic aromatic hydrocarbons using the method of Styles

Dec 1, 1980·Toxicology Letters·W GrebG Röhrborn

Transformation of hamster embryo cells by neutral sterols and bile acids

Oct 1, 1981·Toxicology Letters·M I Kelsey, R J Pienta

Morphological transformation, sister chromatid exchange and mutagenesis assay of betel constituents

Apr 1, 1981·Toxicology Letters·K UmezawaS Takayama

A method for accelerating progression to a malignant phenotype in rodent cells

Jan 1, 1987·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J A PoileyR W Tennant

An interlaboratory evaluation of the Syrian hamster embryo cell transformation assay using eighteen coded chemicals

Jan 1, 1988·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C A JonesR W Tennant

TPA inhibition of gap junctional intercellular communication in Syrian hamster embryo cells through two different pathways

Sep 1, 1993·Toxicology in Vitro : an International Journal Published in Association with BIBRA·L E Roseng, E Rivedal

Effect of protein kinase C inhibitors on TPA-induced inhibition of gap junctional intercellular communication and induction of transformed morphology in Syrian hamster embryo cells

Sep 1, 1993·Toxicology in Vitro : an International Journal Published in Association with BIBRA·L E RosengT Sanner

A simple fluorescence method for the study of the internalization of particles in cultured cells: Application to asbestos and glass fibres

Apr 1, 1994·Toxicology in Vitro : an International Journal Published in Association with BIBRA·S O Mikalsen, K R Modalsli

Role of serum in the morphological transformation of Syrian hamster embryo cells: Characterization and partial purification of protein factors in foetal bovine serum

Apr 1, 1996·Toxicology in Vitro : an International Journal Published in Association with BIBRA·E Rivedal, U Haddeland

Reproductive and chromosomal effects of occupational exposure to lead in the male

Jan 1, 1989·Reproductive Toxicology·C Winder

Enhancement of the morphological transformation of Syrian hamster embryo (SHE) cells by reducing incubation time of the target cells

Apr 6, 2004·Mutation Research·H ZhangB C Myhr

Di-(2-ethylhexyl)phthalate (DEHP) increases Bcl-2/Bax ratio and modifies c-myc expression in Syrian hamster embryo (SHE) cells

Jun 1, 2005·Toxicology Letters·M A MaireP Vasseur

Ilimaquinone inhibits gap-junctional communication prior to Golgi fragmentation and block in protein transport

Jun 12, 2003·Experimental Cell Research·V CrucianiSvein Ole Mikalsen

ZnCl2 induces Syrian hamster embryo (SHE) cell transformation

May 27, 2003·Toxicology Letters·S AlexandreP Vasseur

Morphological transformation and effect on gap junction intercellular communication in Syrian hamster embryo cells as screening tests for carcinogens devoid of mutagenic activity

May 4, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·E RivedalT Sanner

Peroxisome Proliferator-induced Transformation of Syrian Hamster Embryo Cells: Influence of Experimental Procedures

Jun 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·V CrucianiP Vasseur

Relationship between somatic mutation and neoplastic transformation

Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J C Barrett, P O Ts'o

Induction of ouabain-resistant mutations in C3H 10T1/2 mouse cells by ultraviolet light

Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·G L Chan, J B Little

Probabilistic view of the transformation of cultured C3H/10T1/2 mouse embryo fibroblasts by 3-methylcholanthrene

Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A FernandezC Heidelberger

Cellular differentiation and neoplasia: characterization of subpopulations of cells that have neoplasia-related growth properties in Syrian hamster embryo cell cultures

Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S Nakano, P O Ts'o

Malignant transformation induced by incorporated radionuclides in BALB/3T3 mouse embryo fibroblasts

Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P K LeMotteJ B Little

A contact-insensitive subpopulation in Syrian hamster cell cultures with a greater susceptibility to chemically induced neoplastic transformation

Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S NakanoP O Ts'o

Physico-chemical characterization of hamster interferon

Jan 1, 1979·Preparative Biochemistry·E Bollin, E Sulkowski

Simultaneous determination of cellular mutagenesis and transformation by chemical carcinogens in Fischer rat embryo cells

Jan 1, 1978·Journal of Toxicology and Environmental Health·N K MishraF O Thomas

Mutagenicity and transformation by recycled water

Jul 1, 1979·Journal of Toxicology and Environmental Health·N Gruener, M P Lockwood

Tissue distribution and excretion of 2,4-[14C]toluenediamine in the mouse

Jan 1, 1980·Journal of Toxicology and Environmental Health·P D UngerM A Friedman

Comparison of three in vitro assays for carcinogen-induced DNA damage

Mar 1, 1980·Journal of Toxicology and Environmental Health·G S ProbstB J Bewsey

Transformation of Syrian hamster embryo cells by synfuel mixtures

Apr 1, 1983·Journal of Toxicology and Environmental Health·M E Frazier, T K Andrews

Quantitative predictivity of the transformation in vitro assay compared with the Ames test

Oct 1, 1983·Journal of Toxicology and Environmental Health·S ParodiL Santi

Mutagenic and carcinogenic activity of a hydrotreated coal liquid

Jan 1, 1984·Journal of Toxicology and Environmental Health·M E Frazier, D D Mahlum

Cell transformation and promoter activity of insulation oils in the Syrian hamster embryo cell and in the C3H/10T1/2 mouse embryo fibroblast test systems

Jan 1, 1987·Journal of Toxicology and Environmental Health·N AarsaetherT Sanner

Effects of dinitrotoluenes on morphological cell transformation and intercellular communication in Syrian hamster embryo cells

Jan 1, 1990·Journal of Toxicology and Environmental Health·I HolenT Sanner

Production and characterization of monoclonal antibodies against DNA single ring diamines adducts

Apr 1, 1988·Hybridoma·S MariniB Giardina

The Syrian hamster embryo (SHE) assay (pH 6.7): mechanisms of cell transformation and application of vibrational spectroscopy to objectively score endpoint alterations

Dec 8, 2011·Mutagenesis·Abdullah A AhmadzaiFrancis L Martin

ICH guidelines: inception, revision, and implications for drug development

Sep 24, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tao WangWilliam David McGuinn

Effects of hydrocarbons on transformation and intercellular communication in Syrian hamster embryo cells

Jul 1, 1992·Pharmacology & Toxicology·E RivedalI Eide

Transcriptomic effects of di-(2-ethylhexyl)-phthalate in Syrian hamster embryo cells: an important role of early cytoskeleton disturbances in carcinogenesis?

Oct 27, 2011·BMC Genomics·Yann LandkoczP Vasseur

Role of metals in carcinogenesis. Problems of epidemiological evidence

Aug 1, 1981·Environmental Health Perspectives

Recent research on nickel carcinogenesis

Aug 1, 1981·Environmental Health Perspectives·F W Sunderman

Metallic elements in fossil fuel combustion products: amounts and form of emissions and evaluation of carcinogenicity and mutagenicity

Jan 1, 1983·Environmental Health Perspectives·V B Vouk, W T Piver

Transformation of BALB/c-3T3 cells: I. Investigation of experimental parameters that influence detection of spontaneous transformation

Jul 1, 1993·Environmental Health Perspectives·E J Matthews

Mitotic disturbances and micronucleus induction in Syrian hamster embryo fibroblast cells caused by asbestos fibers

Mar 1, 1995·Environmental Health Perspectives·E DoppD Schiffmann

Factors affecting the binding of polycyclic aromatic hydrocarbons to human embryo cells, and transformable and non-transformable hamster embryo cells

Sep 1, 1978·Chemico-biological Interactions·R RaineriR J Pienta

In vitro transformation assays for chemical carcinogens

Aug 1, 1983·Mutation Research·A L Meyer

Genetic effects of naphthylamines

Nov 1, 1982·Mutation Research·V W Mayer

Amitrole-induced cell transformation and gene mutations in Syrian hamster embryo cells in culture

Aug 1, 1984·Mutation Research·T TsutsuiJ C Barrett

DNA damage induced by the antihistaminic drug methapyrilene hydrochloride

Mar 1, 1982·Mutation Research·F R AlthausH C Pitot

Iodomethane human health risk characterization

Jun 13, 2009·Inhalation Toxicology·Beth E MilesonJohn Kinzell

Short-term tests for mutagenesis and carcinogenesis in drug toxicology: how to test and when to test is the question

Jan 1, 1980·Drug Metabolism Reviews·F A De La IglesiaJ E Fitzgerald

Mechanisms of carcinogenicity of methyl halides

Jan 1, 1993·Critical Reviews in Toxicology·H M Bolt, B Gansewendt

Natural carcinogenic products of plant origin

Jun 1, 1981·Critical Reviews in Toxicology·I Hirono

Mutagenic factors in cooked foods

Aug 1, 1979·CRC Critical Reviews in Toxicology·T Sugimura, M Nagao

A critical review of the literature on acrolein toxicity

Jan 1, 1985·Critical Reviews in Toxicology·R O BeauchampH D Heck

Rapid bioassay methods for carcinogens and modifiers of hepatocarcinogenesis

Jan 1, 1989·Critical Reviews in Toxicology·N ItoH Tsuda

Potential radioprotective agents. 2. Substituted anilines

Feb 1, 1994·Journal of Pharmaceutical Sciences·R T BlickenstaffK B Lipkowitz

Role of catalase and oxidative stress in hepatic peroxisome proliferator-induced morphological transformation of Syrian hamster embryo cells

Nov 15, 1990·International Journal of Cancer. Journal International Du Cancer·S O MikalsenT Sanner

Decemtione (Imidan)-induced single-strand breaks to human DNA, mutations at the hgprt locus of V79 cells, and morphological transformations of embryo cells

Jan 1, 1992·Environmental and Molecular Mutagenesis·D SlamenováK Ruppová

Transplacental mutagenesis of products formed in the stomach of golden hamsters given sodium nitrite and morpholine

Sep 15, 1979·International Journal of Cancer. Journal International Du Cancer·N InuiA Tanimura

A rapid in vitro assay for carcinogenicity of chemical substances in mammalian cells utilizing an attachment-independence endpoint

Feb 1, 1979·International Journal of Cancer. Journal International Du Cancer·K A TraulJ S Wolff

Recommended protocol for the Syrian hamster embryo (SHE) cell transformation assay

Dec 27, 2011·Mutation Research·Marie-Aline MaireP Vasseur

Prevalidation study of the Syrian hamster embryo (SHE) cell transformation assay at pH 7.0 for assessment of carcinogenic potential of chemicals

Jan 10, 2012·Mutation Research·Marie-Aline MaireP Vasseur

Effects of serum concentrations on the clonal growth of Syrian golden hamster fetal lung cells

Jan 1, 1979·Experimentelle Pathologie·M EmuraU Mohr

Morphological cell transformation of Syrian hamster embryo (SHE) cells by the cyanotoxin, cylindrospermopsin

Feb 11, 2010·Toxicon : Official Journal of the International Society on Toxinology·M-A MaireP Vasseur

Neoplastic conversion in rat liver by the antihistamine methapyrilene demonstrated by a sequential syncarcinogenic effect with N-2-fluorenylacetamide

Jun 15, 1984·Toxicology and Applied Pharmacology·K Furuya, G M Williams

An enhancing effect of the antihistaminic drug methapyrilene on rat liver carcinogenesis by previously administered N-2-fluorenylacetamide

Aug 1, 1983·Toxicology and Applied Pharmacology·K FuruyaG M Williams

Morphological transformation of Syrian hamster embryo cells by pseudorabies virus related growth factor

May 16, 1994·Cancer Letters·M DusinskaáD Slamenová

Studies of in vitro cell transformation and mutagenicity by surfactants and other compounds

Jun 1, 1980·Food and Cosmetics Toxicology·K InoueS Takayama

Dose responses of five hepatocarcinogens for the initiation of rat hepatocarcinogenesis

Dec 1, 1981·Cancer Letters·K ImaidaN Ito

The importance of short term exposure of C3H 10T1/2 cells to polycyclic hydrocarbons: evidence for hydrocarbon-mediated anticarcinogenic activity

Sep 1, 1981·Cancer Letters·A M SarrifJ R Smythies

Synergistic effect on morphological transformation of hamster embryo cells by nickel sulphate and benz[a]pyrene

Jan 1, 1980·Cancer Letters·E Rivedal, T Sanner

The possibilities of reproducing effects of benzo[a]pyrene in a transformation test using Syrian hamster fetal lung cells

Nov 1, 1979·Cancer Letters·H B Richter-ReichhelmU Mohr

Morphological transformation of Syrian hamster embryo cells by mezerein

Feb 29, 1992·Cancer Letters·A TuJ W Spalding

Modulation of benzo[a]pyrene-induced morphological transformation of Syrian hamster embryo cells by butylated hydroxytoluene and butylated hydroxyanisole

Nov 1, 1986·Cancer Letters·J PotenbergD Henschler

Morphological transformation of Syrian hamster embryo cells by aminobenzyl alcohols and nitrobenzyl alcohols is correlated with intercellular communication

Jul 31, 1990·Cancer Letters·S O Mikalsen

Potentiating effect of cigarette smoke extract on morphological transformation of hamster embryo cells by benzo[alpha]pyrene

Sep 1, 1980·Cancer Letters·E Rivedal, T Sanner

Comparative metabolism of 7,12-dimethylbenz[a]-anthracene and its non-carcinogenic 2-fluoro analogue by Syrian hamster embryo cells

Nov 1, 1983·Cancer Letters·C T OravecL K Wong

Promotional effect of different phorbol esters on morphological transformation of hamster embryo cells

Oct 1, 1982·Cancer Letters·E Rivedal, T Sanner

Effect of 1,1'-(2,2,2-trichloroethylidene)-bis(4-chlorobenzene) (DDT) on gap junctional intercellular communication and morphological transformation of Syrian hamster embryo cells

Jan 1, 1994·Chemico-biological Interactions·L E RosengT Sanner

Effect of glucocorticoids on TPA-induced inhibition of gap-junctional communication and morphological transformation in Syrian hamster embryo cells

Aug 16, 1993·Cancer Letters·L E Roseng, E Rivedal

Strain differences in susceptibility to 2-acetylaminofluorene and phenobarbital promotion of rat hepatocarcinogenesis in a medium-term assay system: quantitation of glutathione S-transferase P-positive foci development

Oct 1, 1989·Japanese Journal of Cancer Research : Gann·M AsamotoS Nagase

Synergism between sodium chloride and sodium taurocholate and development of pepsinogen-altered pyloric glands: relevance to a medium-term bioassay system for gastric carcinogens and promoters in rats

Nov 1, 1989·Japanese Journal of Cancer Research : Gann·M TatematsuN Ito

Chemically-induced unscheduled DNA synthesis in primary rat hepatocyte cultures: a comparison with bacterial mutagenicity using 218 compounds

Jan 1, 1981·Environmental Mutagenesis·G S ProbstS B Neal

Chemical carcinogenesis in vitro: an improved method for chemical transformation in Rauscher leukemia virus-infected rat embryo cells

Feb 1, 1981·Journal of Applied Toxicology : JAT·K A TraulK Wlodymr

Endpoints in short-term tests: significance for carcinogenic potential

Aug 1, 1986·The British Journal of Dermatology·V C Dunkel

A view of the relation between carcinogenesis and mutagenesis

Jan 1, 1989·Environmental and Molecular Mutagenesis·W Lijinsky

Malignant transformation of mammalian cells in culture, including human cells

Jan 1, 1989·Environmental and Molecular Mutagenesis·J McCormick, V M Maher

A rapid in vitro assay for carcinogenicity of chemical substances in mammalian cells utilizing an attachment-independence endpoint. 2 - Assay validation

Jun 1, 1981·Journal of Applied Toxicology : JAT·K A TraulJ S Wolff

Identification of genotoxins: a correlation of bacterial mutation with hepatocyte DNA repair

Jan 1, 1983·Annals of the New York Academy of Sciences·G S ProbstB J Bewsey

Application of transformation systems

Jan 1, 1983·Annals of the New York Academy of Sciences·R J PientaR Raineri

Morphological transformation of C3H/10T1/2 CL8 cells by procarcinogens

Jan 1, 1982·Environmental Mutagenesis·Y Oshiro, P S Balwierz

Variations among species and cell types in the effects of caffeine on mutagen-induced cytotoxicity and postreplication repair of DNA

Jan 1, 1982·Environmental Mutagenesis·A SivakL G Teague

An interlaboratory comparison of transformation in Syrian hamster embryo cells with model and coded chemicals

Jan 1, 1986·Environmental Mutagenesis·A TuE Huberman

Use of the hamster embryo cell transformation assay to detect metabolic activation of N-2-acetylaminofluorene by intact organ cells

Dec 1, 1983·Journal of Applied Toxicology : JAT·J A PoileyR Raineri

Welding fumes and chromium compounds in cell transformation assays

Oct 1, 1985·Journal of Applied Toxicology : JAT·K Hansen, R M Stern

Detection of urinary metabolites of 2-acetylaminofluorene by cultured hamster embryo cells and high performance liquid chromatography

Jan 1, 1980·Teratogenesis, Carcinogenesis, and Mutagenesis·W B LebherzR J Pienta

Simultaneous hyperthermia at 43 degrees C reduces radiation-induced malignant transformation frequencies in golden hamster embryo cells

Apr 15, 1984·International Journal of Cancer. Journal International Du Cancer·M WatanabeT Sugahara

Plasminogen activator synthesis accompanying chemical carcinogen-induced in vitro transformation of Syrian hamster and guinea-pig fetal cells

Sep 15, 1980·International Journal of Cancer. Journal International Du Cancer·E E SisskinJ A Dipaolo

Toxic response of hamster embryo cells on exposure to mixtures of Ni2+ and benzo(a)pyrene

Jun 1, 1986·Journal of Applied Toxicology : JAT·M UzielA Butler

Protein pyrolysate products

Jan 1, 1985·Environmental Mutagenesis·L L Vuolo, G J Schuessler

An evaluation of the genotoxic potential of di-isononyl adipate

Jan 1, 1986·Environmental Mutagenesis·R H McKeeK A Traul

Studies on the mechanism of acetamide hepatocarcinogenicity

Jan 1, 1987·Pharmacology & Toxicology·E DybingS S Thorgeirsson

Short-term bioassays of fractionated emission samples from wood combustion

Jan 1, 1984·Teratogenesis, Carcinogenesis, and Mutagenesis·I AlfheimM Sorsa

Malignant transformation of cryopreserved early passage syrian golden hamster cells by 2-(2-furyl)-3-(5-nitro-2-furyl)-acrylamide

Nov 1, 1978·Cancer Letters·R J PientaS Takayama

A mechanistic evaluation of the Syrian hamster embryo cell transformation assay (pH 6.7) and molecular events leading to senescence bypass in SHE cells

May 14, 2016·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Jessica C PicklesRobert F Newbold

Classification of agents using Syrian hamster embryo (SHE) cell transformation assay (CTA) with ATR-FTIR spectroscopy and multivariate analysis

May 1, 2015·Mutagenesis·Abdullah A AhmadzaiFrancis L Martin

Pharmacological evidence for system-dependent involvement of protein kinase C isoenzymes in phorbol ester-suppressed gap junctional communication

Aug 2, 2001·Experimental Cell Research·V CrucianiS O Mikalsen

In vitro toxicity of welding fumes and their constituents

Aug 1, 1988·Environmental Research·R M SternK M Olsen

An international validation study of a Bhas 42 cell transformation assay for the prediction of chemical carcinogenicity

Aug 2, 2011·Mutation Research·Ayako SakaiN Tanaka

Extensive homology of nuclear ribonucleic acid and polysomal poly(adenylic acid) messenger ribonucleic acid between normal and neoplastically transformed cells

Mar 4, 1980·Biochemistry·R K MoyzisP O Ts'o

Transformation of hamster embryo cells by cholesterol-alpha-epoxide and lithocholic acid

Mar 1, 1979·Cancer Letters·M I Kelsey, R J Pienta

Enhanced survival of ultraviolet-irradiated herpes simplex virus in carcinogen-pretreated cells

Mar 2, 1978·Nature·C D LytleW D Taylor

Comparative effects of carcinogens on the induction of placental glutathione S-transferase-positive liver nodules in a short-term assay and of hepatocellular carcinomas in a long-term assay

Jan 1, 1985·Toxicologic Pathology·T OgisoN Ito

Quantitative correlation with carcinogenic potency of different short term tests

Jan 1, 1984·Toxicologic Pathology·S ParodiL Santi

Malignant transformation of a mouse epithelial cell line with polycyclic aromatic hydrocarbons

Jul 27, 1978·Nature·S Mondal, M Sala

Searches for ultimate chemical carcinogens and their reactions with cellular macromolecules

May 15, 1981·Cancer·E C Miller, J A Miller

The Syrian hamster embryo (SHE) low pH cell transformation assay

Feb 1, 2008·Current Protocols in Toxicology·Kamala Pant, Marilyn J Aardema

Comparative genotoxicity and nephrotoxicity studies of the two halogenated flame retardants tris(1,3-dichloro-2-propyl)phosphate and tris(2,3-dibromopropyl)phosphate

Jan 1, 1985·Acta Pharmacologica Et Toxicologica·E J SøderlundS D Nelson

An overview of short-term tests for the mutagenic and carcinogenic potential of pesticides

Jan 1, 1980·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·M D WatersR Valencia

Animal carcinogenicity studies: 3. Alternatives to the bioassay

Mar 9, 2006·Alternatives to Laboratory Animals : ATLA·Andrew KnightJonathan Balcombe

Mechanisms of chemical carcinogenesis

Mar 1, 1981·Cancer·E C Miller, J A Miller

Metabolic activation of 3-methylcholanthrene and benzo(a)pyrene to mutagens in the L5178Y/TK assay by cultured embryonic rodent cells

Jan 1, 1982·Environmental Mutagenesis·D E AmacherI Zelljadt

Metabolic activation, detoxification and transformation studies with benzo[a]pyrene using rat and hamster organ cells in vitro

Aug 1, 1983·Journal of Applied Toxicology : JAT·R RaineriJ A Poiley

Biological effects of acetamide, formamide, and their mono and dimethyl derivatives: an update

Apr 17, 2001·Critical Reviews in Toxicology·G L Kennedy

Overview of biological mechanisms of human carcinogens

Oct 22, 2019·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Nicholas BirkettDaniel Krewski

Use of a cell transformation assay with established cell lines, and a metabolic cooperation assay with V79 cells for the detection of tumour promoters: a review

Feb 6, 2002·Alternatives to Laboratory Animals : ATLA·Ayako SakaiMakoto Umeda

Cell transformation assays as predictors of human carcinogenicity

Sep 1, 1999·Alternatives to Laboratory Animals : ATLA·R CombesH Yamasaki

Inhibition of morphological transformation induced with N-methyl-N'-nitro-N-nitrosoguanidine in cultures of hamster embryo cells by 5'-bromo-2'-deoxyuridine-photolysis

Sep 15, 1978·International Journal of Cancer. Journal International Du Cancer·S G Mironescu

Related Concepts

Benzpyrene

Tumor Promoters

Neoplastic Cell Transformation

Embryonic Structures, Mammalian

Melting

Cricetus

Methylcholanthrene

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.