Morphologically distinct plaque types differentially affect dendritic structure and organisation in the early and late stages of Alzheimer's disease

Acta Neuropathologica
P A Adlard, J C Vickers

Abstract

We have investigated the effects of the deposition of insoluble beta-amyloid plaques on dendritic morphology within the neocortex. Labelling for beta-amyloid identified three morphologically distinct plaque types present both within the brains of preclinical Alzheimer's disease (AD) and end-stage AD cases. In both preclinical and end-stage AD, the percentage area occupied by diffuse plaques contained a greater density of labelling for microtubule-associated protein-2 (MAP2) relative to the surrounding neuropil (case type, ratio of MAP2 labelling in plaque to MAP2 labelling in surrounding neuropil +/- SEM: preclinical, 1.27+/-0.04; end-stage, 1.32+/-0.05). In contrast, there was a greater density of MAP2-labelled processes surrounding dense-cored plaques compared to that found within the plaque area (preclinical, 0.73+/-0.05; end-stage, 0.62+/-0.07). Fibrillar plaques demonstrated a transition from the early to late stages of AD, with a substantial decrease in the density of MAP2 labelling within the plaque area in end-stage AD cases relative to preclinical AD cases (preclinical, 1.01+/-0.1; end-stage, 0.72+/-0.05). The morphology of dendrites associated with dense-core or fibrillar plaques suggest physical disruption of the neu...Continue Reading

Citations

Nov 19, 2008·Acta Neuropathologica·Adele WoodhouseJames C Vickers
Apr 28, 2005·Expert Review of Neurotherapeutics·Lisa MosconiMony J de Leon
Aug 25, 2004·Journal of Internal Medicine·M J de LeonH Rusinek
Nov 13, 2007·Journal of Neurochemistry·Helena KarlstromPeter R Schofield
Apr 7, 2007·Annals of the New York Academy of Sciences·M J de LeonH Rusinek
May 29, 2004·Neurobiology of Aging·Paul A Adlard, Brian J Cummings
Oct 27, 2011·International Journal of Alzheimer's Disease·Leon M TaiMary Jo Ladu
Apr 20, 2016·Scientific Reports·David S BouvierKeith K Murai
Feb 13, 2020·Journal of Neurotrauma·Jessica M CollinsJenna M Ziebell
Apr 12, 2017·Proceedings of the National Academy of Sciences of the United States of America·Verónica Bobo-JiménezAngeles Almeida
Jan 11, 2005·Neurotoxicity Research·Adele WoodhouseTracey C Dickson
Feb 13, 2020·International Journal of Molecular Sciences·Baruh PolisAbraham O Samson
Feb 15, 2021·Journal of Neurochemistry·Liudmila SosulinaStefan Remy
Sep 26, 2003·The American Journal of Pathology·Eric FalkeSteven E Arnold
Apr 20, 2010·Neurochemistry International·Reza M SalekJulian L Griffin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.