Morphologically distinct types of amyloid plaques point the way to a better understanding of Alzheimer's disease pathogenesis

Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission
Michael R D'Andrea, Robert G Nagele

Abstract

The details of the sequence of pathological events leading to neuron death in Alzheimer's disease (AD) are not known. Even the formation of amyloid plaques, one of the major histopathological hallmarks of AD, is not clearly understood; both the origin of the amyloid and the means of its deposition remain unclear. It is still widely considered, however, that amyloid plaques undergo gradual growth in the interstitial space of the brain via continual extracellular deposition of amyloid beta peptides at "seeding sites," and that these growing plaques encroach progressively on neurons and their axons and dendritic processes, eventually leading to neuronal death. Actually, histopathological evidence to support this mechanism is sparse and of uncertain validity. The fact that the amyloid deposits in AD brains that are collectively referred to as plaques are of multiple types and that each seems to have a different origin often is overlooked. We have shown experimentally that many of the so-called "diffuse amyloid plaques," which lack associated inflammatory cells, are either the result of leaks of amyloid from blood vessels at focal sites of blood-brain barrier breaches or are artifacts resulting from grazing sections through the marg...Continue Reading

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Citations

Apr 1, 2010·Acta Neuropathologica·Gunnar K GourasEstibaliz Capetillo-Zarate
Apr 7, 2012·International Journal of Alzheimer's Disease·Siddhartha Mondragón-RodríguezJannic Boehm
May 2, 2012·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Joshua H K Tam, Stephen H Pasternak
May 4, 2013·Neurochemical Research·Deirdre StolmeierAsgar Zaheer
Jan 22, 2013·Neurochemistry International·Qiuju YuanZhi-Xiu Lin
Jun 4, 2019·Biomolecules·Ruizhi WangShaohua Xu
Oct 5, 2019·Cellular and Molecular Neurobiology·Khalid Bashir DarShowkat Ahmad Ganie
Jan 15, 2020·Canadian Journal of Physiology and Pharmacology·Harmandeep SinghJitender Madan
Mar 16, 2021·American Journal of Alzheimer's Disease and Other Dementias·Aiza KhanConsolato Sergi
Sep 20, 2011·The American Journal of Pathology·Estibaliz Capetillo-ZarateGunnar K Gouras
Jul 12, 2014·Journal of the American Chemical Society·Kristoffer BrännströmAnders Olofsson

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