Morphologically-structured models of growing budding yeast populations

Journal of Biotechnology
Christos Hatzis, Danilo Porro

Abstract

It has been well recognized that many key aspects of cell cycle regulation are encoded into the size distributions of growing budding yeast populations due to the tight coupling between cell growth and cell division present in this organism. Several attempts have been made to model the cell size distribution of growing yeast populations in order to obtain insight on the underlying control mechanisms, but most were based on the age structure of asymmetrically dividing populations. Here we propose a new framework that couples a morphologically-structured representation of the population with population balance theory to formulate a dynamic model for the size distribution of growing yeast populations. An advantage of the presented framework is that it allows derivation of simpler models that are directly identifiable from experiments. We show how such models can be derived from the general framework and demonstrate their utility in analyzing yeast population data. Finally, by employing a recently proposed numerical scheme, we proceed to integrate numerically the full distributed model to provide predictions of dynamics of the cell size structure of growing yeast populations.

References

Mar 1, 1977·Experimental Cell Research·G C JohnstonL H Hartwell
Apr 1, 1979·Journal of Bacteriology·C B TysonA E Wheals
Jan 1, 1991·Bulletin of Mathematical Biology·L Cazzador
Mar 1, 1990·Molecular Microbiology·S M Jazwinski
Jan 11, 1974·Science·L H HartwellB J Reid
Dec 1, 1983·Journal of Bacteriology·M VanoniL Alberghina
Jun 1, 1980·Journal of Bacteriology·P G Lord, A E Wheals
Apr 1, 1982·Molecular and Cellular Biology·A E Wheals
Jan 19, 2000·Molecular Biology of the Cell·K C ChenJ J Tyson
Jun 1, 2004·Molecular Biology of the Cell·Katherine C ChenJohn J Tyson
May 1, 1983·Biotechnology and Bioengineering·L AlberghinaM Vanoni

❮ Previous
Next ❯

Citations

Aug 3, 2010·Acta Biotheoretica·Marie DoumicJorge P Zubelli
Mar 13, 2014·Annual Review of Chemical and Biomolecular Engineering·Doraiswami Ramkrishna, Meenesh R Singh
Jun 20, 2013·The American Naturalist·Thomas M MassieUrsula Gaedke
Oct 30, 2009·Current Opinion in Microbiology·Suzanne S Sindi, Tricia R Serio
Dec 17, 2008·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Danilo PorroChristos Hatzis
Jul 10, 2008·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Meredith E K CalvertLucy F Pemberton
May 5, 2011·Biotechnology Advances·R Lencastre FernandesK V Gernaey
Sep 18, 2007·Yeast·Edda Klipp

❮ Previous
Next ❯

Related Concepts

Related Feeds

Related Papers

Cytometry. Part a : the Journal of the International Society for Analytical Cytology
Danilo PorroChristos Hatzis
Current Opinion in Biotechnology
Michael A Henson
The Biochemical Journal
Michael A HensonMatthias Reuss
© 2021 Meta ULC. All rights reserved