PMID: 9542064May 9, 1998Paper

Morphology and proliferation of B16 melanoma cells in the presence of lanthanoid and Al3+ ions

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
T SatoY Okahata

Abstract

The effects of trivalent metal ions such as lanthanoid (La3+, Ce3+, Nd3+, Sm3+, Gd3+, Er3+, Yb3+, Lu3+) and Al3+ ions on the morphological change and proliferation of B16 melanoma cells in culture are discussed. These metal ions induced morphological transformations and decreased growth rates at doses of 1 mM. B16 melanoma cells treated with La3+, Ce3+, Nd3+, Sm3+, and Gd3+ showed polyhedrical spreading. Elongation of axones was dependent on the metal ions. B16 melanoma cells treated with Er3+, Yb3+, Lu3+, and Al3+ showed a long slender shape. Growth rates of melanoma cells in the presence of 1 mM of metal ions (La3+, Ce3+, Nd3+, Sm3+, Gd3+, Yb3+, Al3+) were significantly lower than that of control cells. Measurements of cell cycle indicated that the metal ions arrested the transitions from G0/G1 to S state.

Citations

May 4, 2005·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ping Shi, Zhiwei Huang
Feb 5, 2008·Biological Trace Element Research·Chen XiaojuanPeng Jianhua
Apr 13, 2011·Biological Trace Element Research·William JenkinsJames Varani
Feb 5, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Xiao-Hui LongJia-Zuan Ni
Jan 22, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Victor M LuHelen E Townley
Oct 23, 2008·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Yu ShiKui Wang
Sep 18, 2009·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Brian D FurmanskiJohn W Fuseler
Mar 31, 2011·Biological Trace Element Research·Ziwei ZhangShiwen Xu
Jan 22, 2003·In Vitro Cellular & Developmental Biology. Animal·Yucheng DaiZhu Wen
Feb 3, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ying ZhangKui Wang
Dec 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Colin UnruhElmar J Prenner
May 1, 2021·Journal of Colloid and Interface Science·Madeleine R FriesFrank Schreiber
Jan 5, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Madeleine R FriesFrank Schreiber

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