PMID: 1212096Jan 1, 1975Paper

Morphology, biochemical analysis and neuraminidase activity of rubella virus

Archives of Virology
G BardelettiM Aymard-Henry

Abstract

A simple and reproducible method for the production of purified rubella virus is described. Purified virus was subjected to morphological and chemical analysis. The virus particles were rather pleomorphic (60 nm diameter), sometimes with one or more peripheral protrusions. The viral surface, revealed by negative staining, was composed of spikes 6 nm long, featuring enlarged ends. In SDS-urea-polyacrylamide gel electrophoresis, 4 major and 4 minor polypeptide bands were revealed. Total lipids and phospholipids were analysed on the same preparation. The viral particles were composed of RNA: 0.030 mg, and lipids: 0.245 mg, of which 0.169 mg were phospholipids for each mg of viral protein. Biologically, the purified virus preparation showed high infectivity, a high hemagglutination titre and a weak neuraminidase activity under defined conditions.

References

Jan 1, 1972·Archiv für die gesamte Virusforschung·G BardelettiD Gautheron
Jul 1, 1969·The Journal of General Virology·A VaheriP Väänänen
Mar 1, 1972·Virology·H Liebhaber, P A Gross
Jan 1, 1972·Journal of Virology·A Vaheri, T Hovi
Mar 9, 1967·The New England Journal of Medicine·G L StewartH M Meyer
Sep 26, 1964·Nature·M STOKER, I MACPHERSON

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Citations

Jan 1, 1981·Archives of Virology·G Bardeletti, A Voiland
Jan 1, 1983·Archives of Virology·V ToivonenT Hyypiä
Jan 1, 1980·Archives of Virology·A Voiland, G Bardeletti
Jan 1, 1980·Archives of Virology·L Ho-Terry, A Cohen
Jul 1, 1989·Journal of Virological Methods·A ThomsonJ P Whiteside
Sep 1, 1984·The Journal of General Virology·N KalkkinenR F Pettersson
Apr 15, 1983·Virology·M N Waxham, J S Wolinsky
Jan 1, 1979·Archives of Virology·R Leprat, M Aymard
Sep 1, 1991·Journal of Clinical Microbiology·H SeppänenC Oker-Blom

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