Jan 1, 1989

Morphology of atopic eczema

Allergy
N A Soter

Abstract

The routine examination of skin biopsy specimens embedded in paraffin and strained with hematoxylin-eosin has failed to allow differentiation of atopic eczema from other types of eczematous dermatitis. The use of 1-micron plastic-embedded sections permits the recognition of infiltrating cell types and blood vessel alterations, thus allowing a refined method to examine cutaneous lesions and permit better definition of cutaneous structures than can be achieved in routinely-processed specimens. Acute vesicular lesions exhibited marked epidermal intercellular edema (spongiosis) and a dermal inflammatory infiltrate of lymphocytes, and activated lymphocytes with normal numbers of mast cells that exhibited various degrees of hypogranulation. Only rare eosinophils, neutrophils, and basophils were noted. Venular alterations included endothelial cell hypertrophy without necrosis. In lichenified plaques there was epidermal hyperplasia with a dermal inflammatory infiltrate that included increased numbers of fully granulated mast cells and increased numbers of lymphocytes and monocyte-macrophages. Alterations of venules included marked endothelial cell hypertrophy and basement membrane thickening. Cutaneous nerves exhibited demyelination an...Continue Reading

  • References9
  • Citations48

References

  • References9
  • Citations48

Citations

Mentioned in this Paper

Eosinophil
Nervousness
Necrosis
Epithelial Hyperplasia of Skin
T-Lymphocyte
Dermatitis, Atopic
Basophils
Mast Cell
SpecimenType - Basophils
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)

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