Morphology of corneal nerves using confocal microscopy

Cornea
L Oliveira-Soto, Nathan Efron

Abstract

The aim of the current study was to evaluate the distribution and morphology of corneal nerves as seen by means of white light confocal microscopy. This study analyzed images of corneal nerves that were obtained using the Tomey Confoscan slit scanning confocal microscope (40x/0.75 objective lens). The images were classified according to their location within the cornea. The objective and subjective evaluation of the images involved measuring, grading, or judging a number of parameters from both individual pictures and from each single nerve fiber within any image. The in vivo observations made in this work are in agreement with those of previous histologic studies. The general scheme of corneal innervation is described as originating from thick and straight stromal nerve trunks that extend lateral and anteriorly and give rise to plexiform arrangements of progressively thinner nerve fibers at several levels within the stroma. From there, nerve fibers perforate Bowman's layer and eventually form a dense neural plexus just beneath the basal epithelial cell layer, which is characterized by tortuous and thin beaded nerve fibers interconnected by numerous nerve elements; nerve fibers from this plexus are known to be responsible for t...Continue Reading

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Citations

Aug 19, 2004·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Wolfgang Artur HerrmannChris Patrick Lohmann
Aug 31, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Oliver StachsRudolf Guthoff
May 22, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Elisabeth M MessmerAnselm Kampik
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Nov 24, 2005·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·N Efron
May 16, 2002·Clinical & Experimental Ophthalmology·Christina N GrupchevaCharles N J McGhee
Aug 7, 2002·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Laura Oliveira-Soto, W Neil Charman
Mar 19, 2003·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Laura Oliveira-Soto, Nathan Efron
Aug 16, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Gemma Caterina Maria RossiPaolo Emilio Bianchi
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