Morphology of early choroidal neovascularisation in age-related macular degeneration: correlation with activity

Eye
J P SarksM C Killingsworth

Abstract

The purpose of this study was to describe the morphology of early choroidal neovascularisation (CNV) and compare the findings in two patients, in the first of whom the vessels appeared inactive and in the second progressive. Changes common to both included a diffuse deposition of membrane coils external to the basement membrane (BsM) of the retinal pigment epithelium (RPE), and macrophages and foreign body giant cells beneath thinned segments of Bruch's membrane (BrM). In the first patient small activated vessels surrounded by enlarged pericytes were found in the choroid beneath these areas and pursued a convoluted course, bulging into or through BrM, but without spreading in the sub-RPE space. This choroidal phase of CNV may be common and unrecognised. In the second patient there was spread of CNV in the sub-RPE space with extravasation of red cells and fibrin. The tips leaking fibrin were covered by a thick BsM-like material and naked endothelial cells were not seen. Pericytes were absent here but were observed at the non-leaking edge. The difference in activity of CNV in the two patients appeared to correlate with the quantity of membranous debris present.

References

Feb 1, 1977·The British Journal of Ophthalmology·Z GregorI H Chisholm
May 1, 1976·The British Journal of Ophthalmology·S H Sarks
Jan 1, 1985·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·P L PenfoldS H Sarks
May 1, 1985·Ophthalmology·W R GreenJ H Yeo
Jan 23, 1987·Science·J Folkman, M Klagsbrun
Jan 1, 1987·Nouvelle Revue Française D'hématologie·A Camez, G Tobelem
Mar 15, 1985·American Journal of Ophthalmology·H MillerS J Ryan
Oct 1, 1989·The American Review of Respiratory Disease·A Antonelli-OrlidgeP A D'Amore
Dec 1, 1973·The British Journal of Ophthalmology·S H Sarks
Jul 1, 1966·Experimental Eye Research·D M MauriceI C Michaelson
Dec 11, 1980·Nature·J Folkman, C Haudenschild
Jun 1, 1994·Archives of Ophthalmology·K Dastgheib, W R Green
Jan 1, 1994·Eye·J P SarksM C Killingsworth
Jun 1, 1995·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M C Killingsworth
Feb 1, 1995·Archives of Ophthalmology·T IshibashiS J Ryan
Jun 1, 1994·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·S SeregardL Berglin

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Citations

Jan 1, 1985·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·E Chihara, N Nao-i
Apr 5, 2001·Progress in Retinal and Eye Research·P L PenfoldJ M Provis
Nov 9, 2001·Drug Discovery Today·Henrik S. RasmussenLisa Wei
Oct 5, 2001·Eye·S Al-HusainyM W Hope-Ross
Oct 6, 2005·Retina·Christine R Gonzales, UNKNOWN VEGF Inhibition Study in Ocular Neovascularization (V.I.S.I.O.N.) Clinical Trial Group
Sep 20, 2005·The British Journal of Ophthalmology·A C BrowningW M Amoaku
Mar 21, 2006·The British Journal of Ophthalmology·M A Zarbin
May 2, 2009·Annual Review of Genomics and Human Genetics·Anand SwaroopGonçalo R Abecasis
Apr 13, 2002·Drugs & Aging·Morten la CourMogens Holst Nissen
Apr 16, 2002·Acta Ophthalmologica Scandinavica·Peep V Algvere, Stefan Seregard
Mar 6, 2008·Seminars in Immunopathology·Steven YehRobert B Nussenblatt
Jan 19, 2005·Retina·Glenn L Stoller, Shaker A Mousa
Apr 16, 2009·Current Opinion in Ophthalmology·Ankoor R Shah, Lucian V Del Priore
Jan 15, 2014·Survey of Ophthalmology·Anton M Kolomeyer, Marco A Zarbin
Mar 20, 2009·Molecular Immunology·Camiel J F BoonAnneke I den Hollander
Nov 26, 2008·Lancet·Hanna R ColemanEmily Y Chew
Dec 15, 2007·Experimental Eye Research·Rūta Motiejūnaite, Andrius Kazlauskas
Nov 1, 2005·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Jan M ProvisMichele C Madigan
Aug 24, 2006·Clinical & Experimental Ophthalmology·Svetlana CherepanoffMark C Gillies
Oct 10, 2013·The Journal of Pathology·Menno van Lookeren CampagneWeilan Ye
Jul 15, 2015·American Journal of Ophthalmology·Laura KuehleweinDavid Sarraf
Jul 1, 2015·Experimental Eye Research·Samuel McLenachanJesus Ruberte
Apr 29, 2015·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Oldrich ChrapekJiri Rehak
Sep 19, 2016·American Journal of Ophthalmology·Chandrakumar BalaratnasingamK Bailey Freund
Apr 7, 2018·European Journal of Ophthalmology·Marco LupidiCarlo Cagini
Sep 7, 2018·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Adrian Will-OrregoStephen H Poor
Jul 18, 2008·Visual Neuroscience·Muriel BoucartAude Oliva
Dec 20, 2008·Visual Neuroscience·Muriel BoucartThomas Desmettre
May 21, 2009·Forensic Science, Medicine, and Pathology·Lutz Roewer
Apr 17, 2014·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Allannah J GaffneyAlison M Binns
Apr 20, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C R ClemensN Eter

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