PMID: 2503918Jul 1, 1989Paper

Morphology of leukocytes from cats affected with alpha-mannosidosis and mucopolysaccharidosis VI (MPS VI)

Veterinary Pathology
J AlroyK L Schunk

Abstract

The morphology and ultrastructure of circulating white blood cells from six Persian and from five Russian Blue/Siamese cats deficient in lysosomal activity of alpha-mannosidase and arylsulfatase B, respectively, were studied and compared to cells from corresponding normal and carrier cats. In cats with mannosidosis, light microscopic examination revealed vacuoles in lymphocytes and monocytes, whereas electron microscopic studies demonstrated additional vacuoles in neutrophils, eosinophils, and basophils. In cats with mucopolysaccharidosis VI (MPS VI), vacuoles containing metachromatic granules were observed in lymphocytes, neutrophils, eosinophils, and monocytes. Ultrastructural studies of these cells identified the accumulation of fibrillar material, which often was associated with lamellated membrane structures.

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Citations

Jul 16, 2003·Journal of Ethnopharmacology·I M HuezaS L Górniak
Jan 1, 1996·Veterinary Clinical Pathology·Jocelyn D. JohnsrudeJohn W. Harvey
Feb 15, 1997·The Journal of Clinical Investigation·A C CrawleyJ J Hopwood
Feb 14, 1998·The Journal of Clinical Investigation·A C CrawleyJ J Hopwood
Jan 11, 1991·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·J AlroyS S Raghavan
Dec 7, 2000·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·C D Warren, J Alroy
Jul 8, 2020·International Journal of Molecular Sciences·Leonie FingerhutNicole de Buhr
Nov 27, 2002·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·B MacrìM Castagnaro

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