Morphology of Microglia Across Contexts of Health and Disease

Methods in Molecular Biology
Julie C SavageMarie-Ève Tremblay

Abstract

Microglia, the brain's resident macrophages, are incredibly plastic and dynamic cells. In this chapter, we aim to describe and classify the many morphological changes they can display in normal development, aging, and disease. Although microglia in healthy adult brain tissue are often ramified with small somas, they can undergo massive and rapid morphological shifts in response to stimuli, becoming amoeboid or hypertrophic. Older animals occasionally contain dystrophic, senescent, and gitter cell-like microglia, and brain injury can be accompanied by an increase in rod cells. By a careful study of microglial morphology, coupled with ultrastructural insights gleaned using electron microscopy, insights can be provided into the functions performed by these various morphological phenotypes.

Citations

May 24, 2020·ASN Neuro·Marie-Kim St-PierreMarie-Ève Tremblay
Dec 12, 2019·Neural Regeneration Research·Ana María Sanchez-Perez
Sep 17, 2020·Medicina·Wojciech DabrowskiKatarzyna Kotfis
Oct 20, 2020·Frontiers in Neuroscience·Micaël CarrierMarie-Ève Tremblay
Jan 3, 2021·Cellular and Molecular Neurobiology·Fillipe M de AraújoMaria Trinidad Herrero
Dec 15, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Stefano RaffaeleMarta Fumagalli
Feb 2, 2021·Frontiers in Pharmacology·Si-Si LinAlexei Verkhratsky
Dec 12, 2020·Frontiers in Cellular Neuroscience·Marie-Eve TremblayAlexei Verkhratsky
Jul 2, 2021·Biological & Pharmaceutical Bulletin·Genki HiramatsuToshiaki Kume
Jul 27, 2021·Pediatric Neurology·Stephen AshwalChristopher G Wilson
Sep 23, 2021·Biological Reviews of the Cambridge Philosophical Society·Marcus Augusto-OliveiraAlexei Verkhratsky

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