Morphology of testicular parenchyma adjacent to germ cell tumours. An interim report

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
J W OosterhuisL H Looijenga

Abstract

A comparative morphological analysis of parenchyma adjacent to testicular germ cell tumours (TGCT) was performed in a series of 181 orchidectomy specimens: 86 with seminomas (Se), 72 with nonseminomatous germ cell tumours (NS) and 23 with combined tumours (CT, which have a Se and a NS component). The following morphological features were semiquantitatively scored: spermatogenesis (modified Johnsen score); amount of tubular atrophy; amount of carcinoma in situ (CIS); amount of intertubular tissue. Absence and presence was scored for the following features: lymphocytic infiltrate surrounding and invading CIS; intratubular seminoma (ISe); intratubular nonseminoma (INS); microlithiasis; diffuse and nodular hyperplasia of Leydig cells; angioinvasiveness; testicular angiopathy. Using non-parametric statistics these features were correlated with each other and with tumour type, tumour size and age of the patient. Se-patients presented at significantly higher age than NS-patients (36 vs 29 years, p=0.001). The age of patients with CT (32 years) was in between that of Se- and NS-patients. No correlation was found between patient age and tumour size. Parenchyma adjacent to Se, compared to parenchyma adjacent to NS had the following signi...Continue Reading

Citations

May 16, 2008·Journal of Genetic Counseling·June A PetersMark H Greene
May 20, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J Wolter Oosterhuis, Leendert H J Looijenga
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Apr 2, 2004·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Judith DonnerMartin Bergmann
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Sep 19, 2008·International Journal of Andrology·N J van CasterenL H J Looijenga
Nov 28, 2014·Andrology·J W OosterhuisL H J Looijenga
Jan 22, 2008·International Journal of Surgical Pathology·Niels J van CasterenLeendert H J Looijenga
Mar 25, 2019·Bulletin du cancer·Morgan TourneYves Allory

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