Morphology-Variable Aggregates Prepared from Cholesterol-Containing Amphiphilic Glycopolymers: Their Protein Recognition/Adsorption and Drug Delivery Applications

Nanomaterials
Zhao WangRuilong Sheng

Abstract

In this study, a series of diblock glycopolymers, poly(6-O-methacryloyl-d-galactopyranose)-b-poly(6-cholesteryloxyhexyl methacrylate) (PMAgala-b-PMAChols), with cholesterol/galactose grafts were prepared through a sequential reversible addition-fragmentation chain transfer (RAFT) polymerization and deprotection process. The glycopolymers could self-assemble into aggregates with various morphologies depending on cholesterol/galactose-containing block weight ratios, as determined by transmission electronic microscopy (TEM) and dynamic laser light scattering (DLS). In addition, the lectin (Ricinus communis agglutinin II, RCA120) recognition and bovine serum albumin (BSA) adsorption of the PMAgala-b-PMAChol aggregates were evaluated. The SK-Hep-1 tumor cell inhibition properties of the PMAgala-b-PMAChol/doxorubicin (DOX) complex aggregates were further examined in vitro. Results indicate that the PMAgala-b-PMAChol aggregates with various morphologies showed different interaction/recognition features with RCA120and BSA. Spherical aggregates (d ≈ 92 nm) possessed the highest RCA120recognition ability and lowest BSA protein adsorption. In addition, the DOX-loaded spherical complex aggregates exhibited a better tumor cell inhibition pr...Continue Reading

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Citations

Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhiyuan Ma, X X Zhu
Oct 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jianghua LiGuangli Yu
Mar 9, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Yuzhen WangYan Fang

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Methods Mentioned

BETA
nanoprecipitation
dynamic light scattering
NMR

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