Morphometric abnormalities in the spleen of the progeny of mice fed epigallocatechin during gestation and nursing

Polish Journal of Veterinary Sciences
Barbara Joanna BałanSławomir Lewicki

Abstract

It is very difficult to cure pregnant females suffering from infections, because of the risk which might occur during treatment by several, even herbal, medications. Many of these substances, among them extracts from plants, have antimicrobial, anti-inflammatory and immunostimulatory properties owing to their polyphenols content, but also may reveal unwanted effects on the fetal development because of their anti-angiogenic properties. The aim of the present study was to elucidate whether daily feeding pregnant and nursing mice 0.2 mg/kg epigallocatechin (EGC), previously recognized as angiogenesis inhibitor, may lead to abnormalities in morphology of spleen and in some parameters of immune function of their adult, 6-week old progeny. Morphometry of EGC offspring spleens revealed lower number of lymphatic nodules and their larger diameter than those found in the control offspring. Cellularity of spleens was lower in EGC offspring than in the controls. Cytometric analysis showed that this decline concerns lymphocytes with CD335 (p<0.001), CD19 (p<0.01) and CD4 (p<0.05) markers. No differences were observed in the humoral response to the immunization with SRBC, and in the proliferative response of splenocytes to mitogens PHA, ConA...Continue Reading

References

Jul 18, 2002·The Journal of Nutritional Biochemistry·Yihai CaoEbba Bråkenhielm
Jul 27, 2005·Journal of Cardiovascular Pharmacology·Chunghui KimJin Han
Oct 28, 2006·Toxicologic Pathology·Mark F Cesta
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Thierry WalzerEric Vivier
Aug 17, 2010·Taiwanese Journal of Obstetrics & Gynecology·Hsiao-Chen TuWen-Hsiung Chan
Oct 30, 2013·Drug and Chemical Toxicology·Yu-Ching Fan, Wen-Hsiung Chan
Jan 1, 2014·Central-European Journal of Immunology·Robert ZdanowskiEwa Skopińska-Różewska
Nov 25, 2016·Experimental and Therapeutic Medicine·Sławomir LewickiWanda Stankiewicz

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Citations

May 6, 2021·International Journal of Environmental Research and Public Health·Bernardo Gindri Dos SantosCristiane Matté

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