Morphometric analysis and clinical followup of isolated prostatic intraepithelial neoplasia in needle biopsy of the prostate

The Journal of Urology
D W KeetchW J Catalona

Abstract

We evaluate the significance of grade and extent of isolated prostatic intraepithelial neoplasia in prostate needle biopsies as a predictor of cancer on repeat biopsy. We reviewed our experience with 58 men 50 years or older who had isolated prostatic intraepithelial neoplasia on initial prostate needle biopsy during a prostate specific antigen (PSA) based screening trial for prostate cancer. All 58 men underwent repeat biopsy to follow the initial findings of prostatic intraepithelial neoplasia. We assessed the relationship of patient age, digital rectal examination, serum PSA concentration, PSA density, prostatic intraepithelial neoplasia grade, number of foci of neoplasia and linear extent of prostatic intraepithelial neoplasia in the initial biopsy specimen to the finding of cancer on the repeat biopsy. We also compared the cancer detection rate in the 58 men with and 427 without prostatic intraepithelial neoplasia in the same screening trial. Of 21 men with low grade and 37 with high grade prostatic intraepithelial neoplasia 4 (19%) and 19 (51%), respectively, had cancer on repeat biopsy (p < 0.02), compared to 82 of 427 (19%) without cancer or prostatic intraepithelial neoplasia on the initial biopsy. High grade prostatic...Continue Reading

References

Apr 25, 1991·The New England Journal of Medicine·W J CatalonaG L Andriole
May 1, 1989·Urology·M K Brawer, P H Lange
Jan 1, 1986·Human Pathology·J E McNeal, D G Bostwick
Jun 1, 1993·Human Pathology·M H Weinstein, J I Epstein

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Citations

Aug 1, 1996·The Prostate·D G BostwickA Lopez-Beltran
Apr 16, 1998·The Prostate·M H WeinsteinJ I Epstein
May 9, 2003·The Urologic Clinics of North America·David G BostwickCory Schlesinger
Jul 15, 2003·Urologic Oncology·Mingxin CheDavid Grignon
Jul 15, 2003·Urologic Oncology·Maxwell V MengGary D Grossfeld
Oct 3, 2007·Prostate Cancer and Prostatic Diseases·G Godoy, S S Taneja
Jan 5, 2000·BJU International·J L BurtonJ B Anderson
Oct 23, 1997·The American Journal of Surgical Pathology·A O ReyesP A Humphrey
Jan 13, 2000·The American Journal of Surgical Pathology·D M BermanJ I Epstein
Sep 8, 2006·Ultrasound Quarterly·Hossein Sadeghi-NejadVikram Dogra
Aug 25, 2004·American Journal of Clinical Pathology·Zhong JiangXiming J Yang
Oct 21, 2000·Journal of Clinical Pathology·R MontironiA Lopez-Beltran
Sep 17, 1999·The American Journal of Pathology·J A DollH Donis-Keller
Apr 25, 2007·Critical Reviews in Clinical Laboratory Sciences·M ChrisofosC Deliveliotis
Sep 24, 1999·The Urologic Clinics of North America·K A Iczkowski, D G Bostwick
Dec 31, 1998·Annals of Diagnostic Pathology·D G Bostwick, K A Iczkowski
Aug 3, 2017·Archives of Pathology & Laboratory Medicine·Francesca Khani, Brian D Robinson
Jun 7, 2012·Korean journal of urology·Joseph C KlinkEric A Klein
Oct 21, 2004·Cancer·David G BostwickBarry Timms
Aug 8, 2006·The Journal of Urology·Brent V YankeIvan Colon

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