Morphometric analysis of amygdla and hippocampus shape in impulsively aggressive and healthy control subjects

Journal of Psychiatric Research
Emil F CoccaroLei Wang

Abstract

Impulsive aggressive behavior is thought to be facilitated by activation of the limbic brain, particularly the amygdala and hippocampus., Functional imaging studies suggest abnormalities in limbic brain activity during emotional information processing in impulsively aggressive subjects with Intermittent Explosive Disorder (IED). It is not known if IED is associated with altered amygdala and hippocampus volume and shape. We examined the volume and shape of the amygdala-hippocampal complex, using morphometric analysis of high resolution structural 3T MR scans in healthy control (HC: n = 73) subjects without history of Axis I or II psychiatric conditions and in subjects with IED (n = 67). While no volume differences were observed between HC and IED subjects, a significant level of morphometric deformation, suggestive of cell loss, in both amygdala and hippocampal structures was observed bilaterally in IED subjects. Analysis of a canonical variable that used the first 10 eigenvectors from both sides of the brain revealed that these morphometric deformations in the IED subjects were not due the presence of confounding variables or to comorbidities among IED subjects. These data reveal that IED is associated with a significant loss o...Continue Reading

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Citations

Nov 7, 2017·The International Journal of Neuropsychopharmacology·Janitza L Montalvo-OrtizEmil F Coccaro
Jul 3, 2018·The European Journal of Neuroscience·Sophie E WalkerCarmen Sandi
Jun 27, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Aurelie PapilloudCarmen Sandi
Apr 15, 2020·Social Psychiatry and Psychiatric Epidemiology·Débora Costa Sena PereiraMaria Carmen Viana
Jul 27, 2017·Journal of Autism and Developmental Disorders·Filippo MuratoriAntonio Narzisi
Nov 13, 2020·Current Psychiatry Reports·Katja BertschSabine C Herpertz
Dec 7, 2019·Neuroscience and Biobehavioral Reviews·Nelly Alia-KleinEdelyn Verona
Feb 8, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ricardo N WernerFelix Aigner

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