Morphometric analysis of arteriolar diameters in experimental nephropathies: application of microvascular casts

Virchows Archiv. A, Pathological Anatomy and Histopathology
K KimuraT Sugimoto

Abstract

Renal arteriolar diameters were measured, using microvascular resin casts, in two hyperfiltration models of rats: the remnants kidney of subtotal nephrectomy (NX) and streptozotocin-induced diabetic kidney (DM). In the NX, the blood pressure was elevated, urinary protein excretion was markedly increased and glomeruli were severely damaged. In the DM, although the blood pressure remained normal, urinary protein excretion was significantly increased and glomeruli were damaged but to a lesser extent than in the NX group. In the NX group, the afferent arteriole was dilated and the efferent arteriole was constricted. In the DM group, the afferent arteriole was dilated, while the efferent arteriole remained unchanged. The results showed that afferent arteriolar dilatation was seen in both the NX and DM groups, possibly leading to the glomerular damage. In the NX group, the systemic high blood pressure and efferent arteriolar constriction augmented glomerular damage significantly.

References

Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·K KimuraT Sugimoto
Dec 14, 1987·The American Journal of Cardiology·M Martínez-MaldonadoL D Dworkin
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Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·H P Volkmann, H Wehner
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Jan 1, 1983·Hypertension·V H GattoneF C Luft
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Citations

Jan 1, 1997·Journal of Clinical Ultrasound : JCU·B Gómez-AnsónR Díaz-González
Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·H Wehner, G Nelischer
Mar 22, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J ItohR Y Osamura
Apr 15, 2008·Current Opinion in Nephrology and Hypertension·Gary S Hill
Sep 25, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mikako HisamichiYugo Shibagaki

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