PMID: 15374431Jul 1, 1991Paper

Morphometric analysis of dermal collagen fibers in normal human skin as a function of age

Archives of Gerontology and Geriatrics
M C BranchetL Robert

Abstract

A quantitative study of dermal collagen as a function of age was carried out by computerized digital image analysis. Fast Green-Syrius Red stained sections were obtained of skin biopsies taken from the upper inner arm of 33 healthy women and 38 healthy men. The Leitz texture Analysis System (Leitz-TAS) and mathematical morphology (Serra, 1982) were used for the evaluation of the data. Collagen was studied in the superficial dermis and also in the reticular dermis using the same program. There were significant correlations, firstly between the percentage of collagen measured by the morphometric method and the concentration of collagen analysed biochemically (microg/mm(2) of tissue section) (r = 0.79, p < 0.001) and secondly between the decreased concentration of collagen and age (r = 0.58, p < 0.05). The morphometrical measurements have shown that the relative percentage of collagen bundles (surface of collagen fibers as a function of the dermal area analyzed) was 93.35% in the superficial dermis and 89.2% in the reticular dermis. Although this value is higher than the chemically determined ratio of collagen to other proteins (over 70%), this may be due to the relatively uniform distribution pattern of (type I and III) collagen ...Continue Reading

References

Apr 1, 1979·Analytical Biochemistry·L C JunquieraR R Brentani
Dec 1, 1975·The British Journal of Dermatology·S ShusterE McVitie
Jan 1, 1990·Gerontology·M C BranchetA M Robert
Aug 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A López-De León, M Rojkind
Jan 1, 1980·Experimental Gerontology·C R HamlinR R Kohn
Nov 1, 1984·Journal of the American Academy of Dermatology·B A Gilchrest

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Citations

Jun 1, 1993·Mechanisms of Ageing and Development·R A Weale
May 1, 1994·Archives of Gerontology and Geriatrics·R Weale
Jan 1, 1995·Experimental Eye Research·R Weale
Jul 1, 1997·Mechanisms of Ageing and Development·R A Weale
Jul 31, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G PéterszegiL Robert
Jul 31, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·I Fodil-BourahlaL Robert
Jun 10, 2016·Scientific Reports·Calebe AlvesBéla Suki
Aug 21, 2018·Advanced Materials·Anna SorushanovaDimitrios I Zeugolis
Mar 4, 2005·The Laryngoscope·J Regan Thomas
Jul 24, 2008·Issues in Mental Health Nursing·Kristine N Williams
Nov 22, 2016·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·K Mizukoshi, K Hirayama
Jan 21, 2004·Archives of Facial Plastic Surgery·Tapan K Bhattacharyya, J Regan Thomas
Jun 22, 2017·Advanced Healthcare Materials·Jangho KimJong Hoon Chung
Dec 10, 2020·International Journal of Biological Macromolecules·Muhammad Waheed IqbalWanmeng Mu

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