Morphometric analysis, ploidy and response to chemotherapy in squamous carcinomas of the head and neck.

Pathology, Research and Practice
T R HelliwellP M Stell

Abstract

The histopathology of 54 squamous carcinomas of the head and neck was evaluated by qualitative grading and morphometry in order to identify those features which predicted a good response to cisplatinum chemotherapy. The histopathology of 66 cases was correlated with tumour ploidy, determined by flow cytometry of paraffin-embedded material, since a separate study has shown that aneuploid carcinomas respond better to chemotherapy. The degree of differentiation was a poor predictor of ploidy, although diploid carcinomas did show more keratin and less nuclear pleomorphism than aneuploid carcinomas. The prominence of nucleoli in tumour cells and the surface area to volume (s/v) ratio of the tumour islands were the variables most strongly correlated with ploidy, with diploid carcinomas having prominent nucleoli and a low s/v ratio. A good response to chemotherapy was related partly to the architecture of the carcinoma (pushing border and low s/v ratio), and partly to the tumour cells (well differentiated) and the percentage of necrotic tumour. A lack of inflammatory reaction or desmoplasia was associated with a poor response. The results indicate that both subjective and objective histopathological criteria may be used to predict plo...Continue Reading

References

Feb 1, 1987·The Journal of Pathology·J Crocker, P Nar
Feb 1, 1988·Journal of Clinical Pathology·D M ParhamR A Brown
Sep 1, 1984·Journal of Clinical Pathology·M L FriedlanderI W Taylor
Jul 1, 1981·Histopathology·J P BaakE Brekelmans
Jan 1, 1981·Cancer·A B MillerA Winkler
Sep 23, 1949·Science·H W ChalkleyH Park

❮ Previous
Next ❯

Citations

Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·P Schmitz-MoormannG W Himmelmann
Aug 26, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·V CanzonieriA Carbone
Dec 31, 2017·The Journal of Pathology·Lee Ad CooperAlexander J Lazar
Apr 2, 1999·Cancer Detection and Prevention·S S ForootanT R Helliwell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.