PMID: 1202286Dec 1, 1975Paper

Morphometric and autoradiographic study of developing ventricular and atrial myocardium in fetal rats

Laboratory Investigation; a Journal of Technical Methods and Pathology
P AnversaA V Loud

Abstract

The ventricular and atrial myocardia of 19- to 21-day-old rat fetuses have been studied by electron microscopic morphometry and quantitative autoradiography following the injection of 3H-leucine. The myocytes in both these regions contain numerous myofibrils located predominantly near the sarcolemma and oriented parallel to each other and to the long axis of the cell. The width of myofibrils at this stage of development is 0.428 +/- 0.240 mum. in the ventricle and 0.365 +/- 0.185 mum. in the atrium. The volume fractions of myofibrils, mitochondria, smooth endoplasmic reticulum, sarcoplasmic matrix, and sarcolemma in ventricular myocytes are nearly equal to the corresponding fractions in atrial cells. A similarity between ventricular and atrial myocytes was also found in the distribution of newly synthesized proteins as indicated autoradiographically by the concentration of grains over various sarcoplasmic structures. In both tissues the concentration of grains was consistently above average over the sarcolemma, smooth endoplasmic reticulum, and myofibrils; average over the mitochondria; and below average in association with the sarcoplasmic matrix. The specificity of this autoradiographic procedure for labeled amino acids actua...Continue Reading

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