PMID: 11925377Apr 2, 2002Paper

Morphometric and cytogenetic characteristics of testicular germ cells and Sertoli cell secretory function in men with non-mosaic Klinefelter's syndrome

Human Reproduction
Yasuhisa YamamotoI Miyagawa

Abstract

Klinefelter's syndrome is the most frequent chromosomal abnormality in infertile men. In this study, the chromosomes of round spermatids and spermatogonia/primary spermatocytes from men with non-mosaic Klinefelter's syndrome were examined, together with the Sertoli cell secretory function and sperm morphometry. Twenty-four men with non-mosaic Klinefelter's syndrome and nine men with obstructive azoospermia underwent therapeutic testicular biopsy. When spermatozoa in the final filtrate were present, they were processed for sperm morphometry or ICSI. Sperm morphometry was evaluated by the maximal length and width of the sperm head, the length of the midpiece and the ratio of the acrosomal region to the total surface area of the head. When round spermatids were present, they were processed for fluorescent in-situ hybridization (FISH). FISH was also applied to fragments of seminiferous tubules. Sertoli cell secretory function was measured by the amount of androgen binding protein (ABP) secreted in vitro. More than 93% of the evaluated round spermatids were normal. The proportions of 24,XY and of 24,XX round spermatids to the total number were significantly larger in men with Klinefelter's syndrome than in obstructed azoospermic men...Continue Reading

Citations

Sep 14, 2002·Prenatal Diagnosis
Jan 6, 2011·Der Urologe. Ausg. A·S KlieschH M Behre
Feb 23, 2011·Journal of Assisted Reproduction and Genetics·Haluk AkinFerda Ozkinay
Oct 15, 2003·Fertility and Sterility·Ulun UlugMustafa Bahceci
Oct 31, 2002·Human Reproduction·J EgozcueF Vidal
Jan 21, 2010·Human Reproduction·G FullertonA Maheshwari
Mar 19, 2013·European Journal of Endocrinology·L Aksglaede, A Juul
Nov 18, 2006·Asian Journal of Andrology·Ioannis GeorgiouNikolaos Sofikitis
Dec 24, 2005·Asian Journal of Andrology·Anurag MitraSatish Kumar Gupta
May 3, 2014·Annales d'endocrinologie·Ingrid PlottonHervé Lejeune
Jun 18, 2014·Gynécologie, obstétrique & fertilité·C RocheJ-N Hugues
Jul 23, 2009·International Journal of Andrology·Y LueR S Swerdloff
Jun 18, 2015·Journal of Assisted Reproduction and Genetics·Alisa Komsky-ElbazDeborah Strassburger
Oct 4, 2008·Current Opinion in Urology·Darius A PaduchJoseph Kiper
May 1, 2014·Expert Review of Endocrinology & Metabolism·Sara Brilli, Gianni Forti
Oct 8, 2019·Expert Review of Endocrinology & Metabolism·Jonathan FainbergPeter N Schlegel
May 16, 2020·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Margo WillemsDorien Van Saen
Sep 21, 2005·Human Reproduction Update·Lise AksglaedeAnders Juul
Dec 12, 2019·Human Reproduction Update·Nicholas A DeebelHooman Sadri-Ardekani
Jun 21, 2020·Journal of Assisted Reproduction and Genetics·Wei ChenZhenbo Zhang
Jan 23, 2021·Problemy e̊ndokrinologii·M V Vorontsova, N Yu Kalinchenko
Dec 29, 2020·Best Practice & Research. Clinical Endocrinology & Metabolism·Nicholas A DeebelHooman Sadri-Ardekani
Aug 26, 2004·Biochimica Et Biophysica Acta·Laura L WoottonFrancesco Michelangeli
Jul 30, 2021·Human Reproduction Update·Nicholas A DeebelHooman Sadri-Ardekani

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