Morphometric and metabolic profile of the distal segment of the internal mammary artery: caution on its use for coronary anastomoses

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
P NatafI Gandjbakhch

Abstract

Elastic arteries were found to be less prone to intimal hyperplasia than muscular arteries. The internal mammary artery (IMA), which is elastic in its proximal segment, presents a gradual decrease of media elastic fibers along its downstream course. Metabolic and morphometric studies of the distal end of the IMA with regard to its local susceptibility to develop intimal changes were undertaken in order to evaluate the reliability of its use as an anastomotic site for bypass grafting. Twenty distal segments of IMA were harvested from patients who had undergone myocardial revascularization. Histologic, enzyme-histochemical and morphometric studies were undertaken on these arterial segments. Histologic examinations indicated an elastomuscular structure in 13 patients, a muscular structure in 6 and an elastic structure in 1. Of the 20 IMAs, none was found to have intimal thickening of greater than 25% of the diameter of the lumen. The enzyme-histochemical profile of the proliferating cells found in the intimal thickening differed from normal contractile smooth muscle medial cells in the loss of myosin and mitochondrial ATPase, plasma membrane 5' nucleotidase, moderately decreased aerobic dehydrogenase and increased lactate dehydrog...Continue Reading

Citations

Jan 5, 2000·The Annals of Thoracic Surgery·J LiskaA Franco-Cereceda
Apr 6, 2000·The Annals of Thoracic Surgery·A LichtenbergA Haverich
Dec 22, 2015·Seminars in Thoracic and Cardiovascular Surgery·Sergey MamchurEgor Malyshenko
Oct 30, 2004·The Journal of Thoracic and Cardiovascular Surgery·Marco PocarFrancesco Donatelli
Dec 29, 2004·The Annals of Thoracic Surgery·Jacob ZeitaniLuigi Chiariello
Apr 25, 2015·The Journal of Thoracic and Cardiovascular Surgery·Gideon SaharDan Aravot
Jan 24, 2006·The Journal of Surgical Research·Peitao WangXing Li Wang
Dec 9, 1998·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·H GöbelG Fraedrich
Feb 10, 2000·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·W C OrejolaH A Mekhjian

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