Morphometric and statistical analyses describing the in utero growth of human epidermis

The Anatomical Record
C A FosterK A Holbrook

Abstract

Epidermal development of human embryonic and fetal skin from the lower limb was studied using morphometric and statistical methods. Epidermal growth, as defined by an increase in epidermal thickness and the number of cell layers, occurred in three distinct stages during the first and second trimesters. The first growth spurt occurred between 5 and 13 weeks estimated gestational age (EGA) and was followed by a plateau phase with little change in epidermal thickness from 14 to 21 weeks, after which the epidermis began to increase in height again. The periderm reached its maximal height by approximately 13 weeks EGA, and by 25 weeks was shed into the amniotic fluid. Thus, within a five-month period (5 to 25 weeks EGA) the epidermis changed from a single cell layer less than 10 micron thick to a 10 to 12-cell layer, keratinized epithelium greater than 60 micron thick. In contrast, epidermis from adult lower limb consisted of about 25 cell layers and was almost 75 micron in thickness. The age-related differences in epidermal thickness probably reflect changes in cell size and shape more than changes in the directional movement (apically vs. laterally) of proliferating keratinocytes, because the addition of cell layers throughout dev...Continue Reading

References

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Citations

Apr 3, 2013·Archives of Dermatological Research·Christopher SchusterAdelheid Elbe-Bürger
Dec 14, 1999·The Journal of Investigative Dermatology·M J HardmanC Byrne
Aug 14, 2009·The Journal of Investigative Dermatology·Yan J JiangKenneth R Feingold

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