PMID: 18723955Aug 30, 2008Paper

Morphometric evaluation of endometrial blood vessels

Indian Journal of Pathology & Microbiology
Divya MakhijaPoornima Baliga

Abstract

Five hundred endometrial specimens were studied to document the changes in blood vessels in various phases of menstrual cycle, menstrual disturbances and in unexplained infertility. Sixty-three cases were taken as control and 437 cases as study group which included cases of dysfunctional uterine bleeding (DUB), endometrial polyps, fibroids, adenomyosis, infertility and atrophic endometrium. Using light microscopy, the vascular morphology was studied. The blood vessels were concentrated more in basal layer in the proliferative phase and in functional layer in the secretory phase. Cases of complex hyperplasia and pill endometrium had significantly higher vessel concentration. Congestion and dilatation of blood vessels were significantly higher in cases of DUB. The present study showed a positive correlation between endometrial angiogenesis and menstrual disorders. The alteration in blood vessel morphology has significant role in prognosis and in various anti-angiogenic therapies.

Citations

Jun 19, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Filomena Marino CarvalhoJoji Ueno
Jun 28, 2011·Menopause : the Journal of the North American Menopause Society·Debra S Heller

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