PMID: 18720554Aug 23, 2008Paper

Morphometric evaluation of the repair of critical-size defects using demineralized bovine bone and autogenous bone grafts in rat calvaria

Clinical Oral Implants Research
Rodrigo Cardoso de OliveiraJośe Mauro Granjeiro

Abstract

To evaluate the repair of critical-size bone defects in rats treated with demineralized bovine bone (DBB) compared with autogenous bone (AB). A bone defect of 8 mm in diameter was created in the calvaria of 50 Rattus norvegicus, treated either with DBB or AB. Sub-groups of five rats of each group were killed at 7, 14, 21, 30 and 90 days post-operatively, and the skulls were removed and processed histologically. Histological sections were stained with hematoxylin and eosin. Histological analysis showed complete closure of the defects with new bone at 90 days in group AB, and substitution of the biomaterial by fibrotic connective tissue in the DBB group at 21 days. Morphometric analysis showed that DBB was rapidly absorbed at 14 days, with its volume density decreasing from 47%+/-0.8% at 7 days to 1.2%+/-0.41% at 14 days. Subsequently, volume densities of the connective tissue and neoformed bone increased from 51.1%+/-11.17% to 86.8%+/-7.92% and from 1.9%+/-1.13% to 12%+/-8.02%, respectively, for the same time interval. The volume density of AB particles did not change throughout the experimental periods, but the amount of new bone increased markedly between 7 and 90 days, from 4.5%+/-1.57% to 53.5%+/-6.42% (P<0.05). DBB did not ...Continue Reading

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Citations

Sep 18, 2013·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Xana Raquel OrtolanFátima de Campos Buzzi
Aug 11, 2012·Odontology·Mileni da Silva FernandesRodrigo Cardoso de Oliveira
Mar 24, 2011·Clinical Oral Implants Research·Willian Fernando ZambuzziJosé Mauro Granjeiro
May 25, 2012·Journal of Biomedical Materials Research. Part a·Tsai-Chin ShihNai-Chia Teng
Mar 31, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Manisha C YadavJosé Luis Millán
Mar 26, 2013·Journal of Biomedical Materials Research. Part a·Tsai-Chin ShihWei-Jen Chang
Feb 21, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Lídia Ágata de SenaCarlos Alberto Achete
Jul 4, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Dénes B HorváthyZsombor Lacza
Apr 28, 2016·Journal of Applied Oral Science : Revista FOB·Maíra Cavallet de AbreuEdela Puricelli
Oct 28, 2018·Journal of Periodontology·Igor Guimarães Barros Paulinelli SantosRonaldo Barcellos de Santana
Jun 9, 2016·Tissue Engineering and Regenerative Medicine·Woo-Sung Choi, Hyun-Joong Yoon
Feb 2, 2017·Journal of Lasers in Medical Sciences·Eliziane Cossetin VasconcelosAroline Nemetz Bronfman

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