PMID: 525935Sep 1, 1979Paper

Morphometric study of experimentally induced Staphylococcus bovis mastitis in the cow

American Journal of Veterinary Research
C W Heald

Abstract

Comparisons were made of bovine mammary tissue at 12 and 24 hours after 5,000 colony-forming units of Staphylococcus aureus 305 was injected into the mammary parenchyma with control tissue from the contralateral udder half. A mild form of staphylococcal mastitis was induced routinely. Generally, S aureus was found in udder tissue removed centrally from the site of injection. Varied degrees of tissue damage were found in infected quarters from alveolar epithelium without damage (similar to control) to extremely swollen epithelium which were typical of cells undergoing disruption. Infected tissues frequently displayed areas of swollen stroma and areas of diminished alveolar lumens. Cellular debris was often found in lumens, and neutrophils frequently filled the alveolar lumen in areas of greatest damage. Thus, a parenchymal injection of bacteria induced early forms of staphylococcal mastitis at the alveolar level.

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