Morphometric study of regeneration through vascularized nerve graft in a rabbit sciatic nerve model

Journal of Reconstructive Microsurgery
K C Tark, T S Roh

Abstract

Adequate vascularization is essential for a successful nerve graft. Theoretically, immediate vascularization will minimize fibroblast infiltration and support axonal regeneration. In this study, histomorphologic and morphometric studies were carried out to determine whether vascularized grafts are beneficial, in terms of axonal regeneration. In a rabbit model, 4-cm segments of sciatic nerve were obtained and placed as a nonvascularized graft on one side, and as a pedicled vascularized graft fed by the inferior gluteal vessel on the contralateral side. Histomorphologically, the distribution of myelinated nerve fibers and Schwann cells was evaluated after toluidine blue staining, at 2-, 3-, and 4-month intervals. The following results were obtained. 1) Myelinated nerve fibers were more abundant in the proximal, middle, and distal segments of the vascularized nerve group at 2 and 3 months. 2) The average nerve-fiber diameter was greater in the vascularized nerve graft group at 2, 3, and 4 months (2 to 10 microm). 3) Schwann cells were more abundant in the proximal, middle, and distal segments of the vascularized nerve graft group at all time points. Based on the above findings, the immediate restoration of circulation in the vascu...Continue Reading

Citations

Dec 31, 2003·Biomaterials·J IJkema-PaassenM F Meek
Feb 25, 2010·Annals of Plastic Surgery·Savaş SerelAylin Okçu Heper
Jul 31, 2013·Hand Clinics·Michael Y LinRanjan Gupta
Feb 10, 2010·The Journal of Hand Surgery·Mohamed ShafiKazuteru Doi
Jun 29, 2016·Neurological Research·Renato DonzelliFrancesco Maiuri
Jan 30, 2015·Plastic and Reconstructive Surgery·Yun ZhuWenjun Yang

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