Morphometry and gyrification in bipolar disorder and schizophrenia: A comparative MRI study.

NeuroImage. Clinical
Nuno MadeiraMiguel Castelo-Branco

Abstract

Schizophrenia is believed to be a neurodevelopmental disease with high heritability. Differential diagnosis is often challenging, especially in early phases, namely with other psychotic disorders or even mood disorders. such as bipolar disorder with psychotic symptoms. Key pathophysiological changes separating these two classical psychoses remain poorly understood, and current evidence favors a more dimensional than categorical differentiation between schizophrenia and bipolar disorder. While established biomarkers like cortical thickness and grey matter volume are heavily influenced by post-onset changes and thus provide limited possibility of accessing early pathologies, gyrification is assumed to be more specifically determined by genetic and early developmental factors. The aim of our study was to compare both classical and novel morphometric features in these two archetypal psychiatric disorders. We included 20 schizophrenia patients, 20 bipolar disorder patients and 20 age- and gender-matched healthy controls. Data analyses were performed with CAT12/SPM12 applying general linear models for four morphometric measures: gyrification and cortical thickness (surface-based morphometry), and whole-brain grey matter/grey matter v...Continue Reading

Citations

Mar 7, 2021·Journal of Personalized Medicine·Jinya SatoToshiaki Onitsuka
Aug 15, 2021·The European Journal of Neuroscience·Joana CrisóstomoMiguel Castelo-Branco

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Software Mentioned

VBM
SPSS Statistics
SPM12
MEDPERSYST
BIGDATIMAGE
CAT12
FreeSurfer

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