PMID: 2496519Jan 1, 1989Paper

Morphometry of terminal hepatic veins. 2. Follow up in chronically alcohol-fed baboons

Virchows Archiv. A, Pathological Anatomy and Histopathology
L C PortoJ A Grimaud

Abstract

Alcohol induced perivenular fibrosis of terminal hepatic veins (THV) is claimed to be a precursor lesion leading to fibrosis development in man and baboon. The nature and significance of the THV lesions found in four baboons chronically fed with alcohol were studied in liver biopsies obtained during a three year period. The surface of THV wall and the number of mesenchymal cells were assessed with a semi-automatic image analyser. Histologically, THV were characterized as (a) phlebitic, in the presence of an inflammatory cell infiltrate involving the venous wall; (b) oedematous, when the connective tissue of the THV wall was disrupted or dissociated and (c) fibrotic, when perivenular scarring appeared as an increased rim. These lesions were present simultaneously and their intensity and distribution were independent of the duration of alcohol intoxication. Morphometric data obtained from these THV confirmed the thickening of the THV wall (WS/IS in: oedematous 1.05 +/- 0.36; phlebitic 1.65 +/- 1.04; fibrotic 1.47 +/- 0.36); and revealed an increased number of mesenchymal cells in fibrotic (439 microns 2/cell; p less than 0.01) and in phlebitic THV (510 microns 2/cell; p less than 0.05). A constant relationship was found between p...Continue Reading

References

Jan 1, 1976·Frontiers of Gastrointestinal Research·G Ugarte, H Iturriaga
Feb 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·C S LieberE Rubin
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·L C PortoJ A Grimaud
Aug 1, 1986·Seminars in Liver Disease·R N MacSween, A D Burt
Jan 1, 1986·Alcoholism, Clinical and Experimental Research·C S Davidson
Jan 1, 1986·Journal of Clinical Pathology·A D Burt, R N MacSween
Jan 1, 1974·Journal of Medical Primatology·C S Lieber, L M DeCarli
Jul 1, 1984·Journal of Clinical Pathology·K A Fleming, J O McGee
Jul 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y MinatoJ Takeuchi
Jan 1, 1982·British Medical Bulletin·P J Scheuer

❮ Previous
Next ❯

Citations

Jan 1, 1991·Drug and Alcohol Review·C S Lieber
Aug 1, 1991·Alcoholism, Clinical and Experimental Research·C S Lieber
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·M S de AraújoJ A Grimaud
Sep 1, 1993·Baillière's Clinical Gastroenterology·C S Lieber
May 1, 1991·Journal of Hepatology·C S Lieber, L M DeCarli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.