PMID: 7524234Oct 1, 1994Paper

Morphometry of the prostate: I. Distribution of tissue components in hyperplastic glands

Urology
L S MarksJ B deKernion

Abstract

Morphometry, or quantitative image analysis, offers great promise in characterizing the various histologic types of benign prostatic hyperplasia (BPH), but to date, a systematic study of the tissue components is lacking. Thus we employed morphometry to examine the distribution of primary BPH tissues throughout whole human prostates. The prostate glands of 20 men with BPH were removed for low-volume carcinoma and subjected to a uniform, comprehensive, systematic quantification of the primary BPH tissue components using the technique of digitization and point-count morphometry. We found the following average volumes among the 20 glands: epithelium, 19.9% (S.D. 5.1%, range 11.7% to 30.8%); fibromuscular stroma, 50.4% (S.D. 9.4%, range 32.2% to 74.4%); glandular lumina, 29.7% (S.D. 8.9%, range 11.9% to 47.5%). Within the individual prostates, we found symmetry in primary BPH tissue distribution, except that the outer prostate was on average 25% richer in epithelium than the inner prostate (p < 0.05). When tissue composition was determined in simulated biopsy specimens, corrected for radial (ie, inner vs outer gland) orientation, the correlation with whole-organ composition was statistically significant for "percentage epithelium" (...Continue Reading

References

Jan 1, 1990·European Urology·Y I SiegelA Lindner

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Citations

Oct 16, 2012·Cell Biology and Toxicology·Maria Notara, Aamir Ahmed
Mar 30, 1999·Urology·L S MarksJ B deKernion
May 1, 1997·International Journal of Radiation Oncology, Biology, Physics·S P LankfordG K Zagars
Apr 22, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B FriedrichS A Loening
Feb 13, 2001·International Journal of Andrology·M I ArenasR Paniagua
Dec 1, 1996·Journal of Endourology·J S WolfR V Clayman
Nov 18, 2000·Journal of Endourology·D L Floratos, R G Aarnink
Dec 26, 2001·Current Opinion in Urology·Christian SeitzMichael Marberger
Nov 1, 2000·The Prostate. Supplement·C S Foster
Mar 23, 2017·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Simon RobinsonBruce Montgomery
Sep 25, 1997·The Journal of Urology·A V D'AmicoA Wein
Jul 25, 2014·American Journal of Physiology. Renal Physiology·Thomas KunitMartin Hennenberg
Aug 1, 1996·Scandinavian Journal of Urology and Nephrology·A AtanT Hald
Jan 29, 2017·Journal of Magnetic Resonance Imaging : JMRI·Shirin SabouriPiotr Kozlowski
Aug 31, 2002·Human Pathology·Michael P ViglioneJonathan I Epstein
Oct 13, 2006·Radiologic Clinics of North America·Neil F Wasserman

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