Morroniside cinnamic acid conjugate as an anti-inflammatory agent.

Bioorganic & Medicinal Chemistry Letters
Yoshinori TakedaMamoru Koketsu

Abstract

A morroniside cinnamic acid conjugate was prepared and evaluated on E-selectin mediated cell-cell adhesion as an important role in inflammatory processes. 7-O-Cinnamoylmorroniside exhibited excellent anti-inflammatory activity (IC(50)=49.3 microM) by inhibiting the expression of E-selectin; further, it was more active than another cinnamic-acid-conjugated iridoid glycoside (harpagoside; IC(50)=88.2 microM), 7-O-methylmorroniside, and morroniside itself. As a result, 7-O-cinnamoylmorroniside was observed to be a potent inhibitor of TNF-alpha-induced E-selectin expression.

Citations

Feb 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fatima Ez-Zahra AmratiDalila Bousta
Jul 2, 2019·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Shan XiongZhenqing Zhang

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