Mortality and host response aberrations associated with transient and persistent acute kidney injury in critically ill patients with sepsis: a prospective cohort study.

Intensive Care Medicine
Fabrice UhelMARS consortium

Abstract

Sepsis is the most frequent cause of acute kidney injury (AKI). The "Acute Disease Quality Initiative Workgroup" recently proposed new definitions for AKI, classifying it as transient or persistent. We investigated the incidence, mortality, and host response aberrations associated with transient and persistent AKI in sepsis patients. A total of 1545 patients admitted with sepsis to 2 intensive care units in the Netherlands were stratified according to the presence (defined by any urine or creatinine RIFLE criterion within the first 48 h) and evolution of AKI (with persistent defined as remaining > 48 h). We determined 30-day mortality by logistic regression adjusting for confounding variables and analyzed 16 plasma biomarkers reflecting pathways involved in sepsis pathogenesis (n = 866) and blood leukocyte transcriptomes (n = 392). AKI occurred in 37.7% of patients, of which 18.4% was transient and 81.6% persistent. On admission, patients with persistent AKI had higher disease severity scores and more frequently had severe (injury or failure) RIFLE AKI stages than transient AKI patients. Persistent AKI, but not transient AKI, was associated with increased mortality by day 30 and up to 1 year. Persistent AKI was associated with ...Continue Reading

Associated Clinical Trials

References

May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patrick N CunninghamRichard J Quigg
Aug 18, 2004·Critical Care : the Official Journal of the Critical Care Forum·Rinaldo BellomoUNKNOWN Acute Dialysis Quality Initiative workgroup
Aug 18, 2005·JAMA : the Journal of the American Medical Association·Shigehiko UchinoUNKNOWN Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators
Apr 28, 2006·Kidney International·C LangenbergR Bellomo
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Lakhmir S ChawlaWilliam L Macias
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Sean M BagshawUNKNOWN Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators
Mar 8, 2008·Critical Care : the Official Journal of the Critical Care Forum·Christoph LangenbergRinaldo Bellomo
Mar 28, 2008·Critical Care : the Official Journal of the Critical Care Forum·Filippo MarianoGiovanni Camussi
Apr 8, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sean M BagshawUNKNOWN Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators
Jun 24, 2009·Intensive Care Medicine·Michael JoannidisPhilipp G H Metnitz
Feb 11, 2010·Critical Care : the Official Journal of the Critical Care Forum·Charalampos Pierrakos, Jean-Louis Vincent
Mar 31, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maryam NejatZoltán H Endre
Oct 29, 2010·Nature Reviews. Nephrology·Chirag R Parikh, Steven G Coca
Jan 26, 2013·American Journal of Respiratory and Critical Care Medicine·Osamu TakasuRichard S Hotchkiss
Jan 29, 2013·Critical Care Medicine·R Phillip DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup
Oct 16, 2013·Critical Care Medicine·Christoph LangenbergRinaldo Bellomo
Nov 2, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Xiaoxi ZengSushrut S Waikar
Dec 3, 2013·Critical Care : the Official Journal of the Critical Care Forum·Matthieu LegrandDidier Payen
Jun 15, 2014·Journal of Critical Care·Manish M SoodUNKNOWN Cooperative Antimicrobial Therapy in Septic Shock (CATSS) Database Research Group
Mar 1, 2012·Kidney International Supplements
Jan 9, 2015·Journal of the American Society of Nephrology : JASN·John A KellumGilles Clermont
Jan 21, 2015·Critical Care : the Official Journal of the Critical Care Forum·Henrik GammelagerHenrik Toft Sørensen
May 7, 2015·Critical Care : the Official Journal of the Critical Care Forum·Claire Rimes-StigareMax Bell
Jun 30, 2015·American Journal of Respiratory and Critical Care Medicine·Brendon P SciclunaTom van der Poll
Jul 15, 2015·Intensive Care Medicine·Eric A J HosteJohn A Kellum
Sep 24, 2015·American Journal of Respiratory and Critical Care Medicine·John A KellumUNKNOWN ProCESS and ProGReSS-AKI Investigators
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Mar 10, 2016·Blood·Theodora A M ClaushuisUNKNOWN Molecular Diagnosis and Risk Stratification of Sepsis Consortium
Mar 12, 2016·American Journal of Respiratory and Critical Care Medicine·Matthew J MaidenRinaldo Bellomo
Mar 16, 2016·JAMA : the Journal of the American Medical Association·Lonneke A van VughtUNKNOWN MARS Consortium
Jun 24, 2016·Annals of Intensive Care·Cong-Juan LuoXiang-Mei Chen
Sep 17, 2016·American Journal of Respiratory and Critical Care Medicine·John A KellumLakhmir S Chawla
Jan 20, 2017·Intensive Care Medicine·Andrew RhodesR Phillip Dellinger
Jan 25, 2017·Nature Reviews. Disease Primers·Richard S HotchkissJean-Louis Vincent
Feb 28, 2017·Nature Reviews. Nephrology·Lakhmir S ChawlaUNKNOWN Acute Disease Quality Initiative Workgroup 16.
Apr 2, 2017·Intensive Care Medicine·Rinaldo BellomoAntoine Schneider
Apr 25, 2017·Nature Reviews. Immunology·Tom van der PollMihai G Netea
May 4, 2017·Intensive Care Medicine·L G ForniM Joannidis
Oct 4, 2017·American Journal of Respiratory and Critical Care Medicine·Brendon P SciclunaTom van der Poll
Jan 20, 2018·American Journal of Respiratory and Critical Care Medicine·Stéphane GaudryDidier Dreyfuss
Mar 20, 2018·Journal of Intensive Care Medicine·Horng-Ruey ChuaAmartya Mukhopadhyay

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT01905033

Software Mentioned

R Foundation for Statistical Computing
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.