Mortality and morbidity from malaria after stopping malaria chemoprophylaxis

Transactions of the Royal Society of Tropical Medicine and Hygiene
Brian GreenwoodR W Snow

Abstract

Gambian children who had received malaria chemoprophylaxis for a variable period of time during their first 5 years of life were followed to determine whether they experienced a rebound in mortality or in morbidity from malaria during the period after chemoprophylaxis was stopped. The risk of dying between the ages of 5 years, when chemoprophylaxis was stopped, and 10 years was no higher among children who had received chemoprophylaxis with Maloprim (pyrimethamine plus dapsone) for some period during their first 5 years of life than among children who had received placebo (21 vs. 24 deaths) and the beneficial effect of chemoprophylaxis on mortality observed during the first 5 years of life was sustained. The incidence of clinical attacks of malaria during the year after medication was stopped was significantly higher among children who had previously received Maloprim for several years than among children who had previously received placebo. However, at the end of this year, there was no significant difference in spleen rate, parasite rate or packed cell volume between the 2 groups of children. Thus, stopping chemoprophylaxis after a period of several years increased the risk of clinical malaria but did not result in a rebound ...Continue Reading

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Citations

Aug 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·H P BeckC Menendez
Aug 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·M TannerT Smith
Oct 24, 2000·Tropical Medicine & International Health : TM & IH·H EkvallA Björkman
Nov 3, 2007·Current Opinion in Infectious Diseases·Martin P GrobuschRobert D Newman
May 31, 2007·Journal of Paediatrics and Child Health·Sally Munday
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Apr 17, 2012·Malaria Journal·Machteld E BoelRose McGready
Jul 22, 2005·Malaria Journal·Wendy Prudhomme O'MearaF Ellis McKenzie
Jul 9, 2011·Trends in Molecular Medicine·Steffen Borrmann, Kai Matuschewski
Jan 28, 2012·Journal of Medical Microbiology·Else M Bijker, Robert W Sauerwein
Jul 25, 2015·Malaria Journal·Peter Pemberton-RossMelissa A Penny
Jul 11, 2012·Expert Opinion on Pharmacotherapy·Azucena BardajíClara Menéndez
Jun 4, 2008·Malaria Journal·Waraphon PhimpraphiPratap Singhasivanon
Jun 15, 2007·Memórias do Instituto Oswaldo Cruz·Carlos Eduardo Tosta
May 12, 2010·Expert Review of Anti-infective Therapy·Roly D GoslingDaniel Chandramohan
Feb 18, 2012·The Cochrane Database of Systematic Reviews·Martin M MeremikwuChioma Oringanje
Dec 7, 2019·Malaria Journal·Thomas A SmithNakul Chitnis

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