PMID: 2861311Jun 15, 1985Paper

Mortality and morbidity results from the European Working Party on High Blood Pressure in the Elderly trial

Lancet
A AmeryF Forette

Abstract

A double-blind randomised placebo-controlled trial of antihypertensive treatment was conducted in patients over the age of 60. Entry criteria included both a sitting diastolic blood pressure on placebo treatment in the range 90-119 mm Hg and a systolic pressure in the range 160-239 mm Hg. 840 patients were randomised either to active treatment (hydrochlorothiazide + triamterene) or to matching placebo. If the blood pressure remained raised, methyldopa was added to the active regimen and matching placebo in the placebo group. An overall intention-to-treat analysis, combining the double-blind part of the trial and all subsequent follow-up, revealed a non-significant change in total mortality rate (-9%, p = 0.41) but a significant reduction in cardiovascular mortality rate (-27%, p = 0.037). The latter was due to a reduction in cardiac mortality (-38%, p = 0.036) and a non-significant decrease in cerebrovascular mortality (-32%, p = 0.16). In the double-blind part of the trial, total mortality rate was not significantly reduced (-26%, p = 0.077). Cardiovascular mortality was reduced in the actively treated group (-38%, p = 0.023), owing to a reduction in cardiac deaths (-47%, p = 0.048) and a non-significant decrease in cerebrovas...Continue Reading

Citations

May 13, 2009·Archives of Internal Medicine·Jackson T WrightUNKNOWN ALLHAT Collaborative Research Group
Mar 1, 1990·Clinical Cardiology·M LehmannA Schmid
Aug 1, 1991·Clinical Cardiology·W B RogersM J Frank
Jun 1, 1991·Journal of Clinical Pharmacology·T D GilesM A Sirgo
Dec 1, 1992·Cardiovascular Drugs and Therapy·L H Opie
Dec 1, 1992·Cardiovascular Drugs and Therapy·A AmeryP W de Leeuw
Dec 1, 1992·Cardiovascular Drugs and Therapy·M Moser
Dec 1, 1992·Cardiovascular Drugs and Therapy·J I Robertson
Jan 1, 1990·Cardiovascular Drugs and Therapy·S T McCarthyS E Gould
Sep 1, 1988·Cardiovascular Drugs and Therapy·W H BirkenhägerJ Staessen
Jan 1, 1991·Cardiovascular Drugs and Therapy·G H Rutan
Jan 1, 1991·Cardiovascular Drugs and Therapy·P A PhillipsC I Johnston
Jan 1, 1991·Cardiovascular Drugs and Therapy·S Strandgaard
Jan 1, 1991·Cardiovascular Drugs and Therapy·J StaessenA Amery
Jan 1, 1991·Cardiovascular Drugs and Therapy·J L Dall
Dec 1, 1991·Cardiovascular Drugs and Therapy·J D Swales
Dec 1, 1991·Cardiovascular Drugs and Therapy·J R Hampton
Jun 1, 1989·Cardiovascular Drugs and Therapy·M D Feher, D J Betteridge
Feb 1, 1994·Cardiovascular Drugs and Therapy·C R Swanepoel
Aug 1, 1994·Cardiovascular Drugs and Therapy·J I Robertson
Aug 1, 1993·Cardiovascular Drugs and Therapy·E G LakattaA H Gradman
Dec 1, 1993·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·D A SclarM A Gill
Oct 1, 1989·Cardiovascular Drugs and Therapy·J R Hampton
Oct 1, 1989·Cardiovascular Drugs and Therapy·O RománA Valenzuela
Dec 1, 1989·Cardiovascular Drugs and Therapy·I J Perry, D G Beevers
Aug 1, 1990·Cardiovascular Drugs and Therapy·P Larochelle
Dec 1, 1990·Cardiovascular Drugs and Therapy·R E Schmieder, J K Rockstroh
Nov 1, 1987·Journal of General Internal Medicine·W Engel, J Sawyer
Nov 1, 1987·Journal of General Internal Medicine·C H Hennekens
Mar 1, 1991·Aging : Clinical and Experimental Research·T L Bush
Dec 1, 1991·Aging : Clinical and Experimental Research·F ForetteP W De Leeuw
Jun 1, 1992·Aging : Clinical and Experimental Research·A Fletcher, C Bulpitt
Sep 1, 1992·Aging : Clinical and Experimental Research·F ForetteF Boller
Apr 19, 2005·Der Internist·A Hartmann, S Moskau
Aug 6, 2005·European Journal of Clinical Pharmacology·Elisabetta PoluzziNicola Montanaro
Nov 1, 2005·Zeitschrift für Kardiologie·G BönnerG Sauer
Dec 21, 2000·Current Atherosclerosis Reports·E Bruckert
Sep 12, 2000·Current Hypertension Reports·S P Glasser
Jul 27, 2001·Current Hypertension Reports·J G Wang, J A Staessen
May 7, 2004·Current Hypertension Reports·Olivier HanonFrançoise Forette

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