PMID: 8447526Feb 1, 1993Paper

Mortality and sequelae due to cerebral malaria in African children in Brazzaville, Congo

The American Journal of Tropical Medicine and Hygiene
B CarmeH Plassart

Abstract

This study was carried out on 170 children admitted to the University Hospital of Brazzaville (Congo) for cerebral malaria between January 1, 1988 and June 30, 1989. The selection criteria were 1) unarousable coma, cerebrospinal fluid without microorganisms or a marked cellular reaction, and the absence of other causes, and 2) that the children lived in Brazzaville. The case fatality rate was 15%. In 75% of the cases, death occurred within the first 48 hr. The prognosis worsened with the stage of the coma and a younger age. At discharge from the hospital, 9% of the cases presented with sequelae. The postcerebral malaria mortality was high; indeed, death occurred in six (7%) of 90 children discharged from the hospital whose parents were contacted between nine and 27 months later. Two deaths were directly related to neurologic sequelae. Among the 58 children examined under satisfactory conditions between nine and 27 months (mean 16.9 months) after discharge, 50% (3 of 6) still presented with attenuated forms of the sequelae observed immediately after the episode of cerebral malaria (cortical blindness had regressed completely, unlike ataxia and loss of balance). Disorders that may have been related to the episode of cerebral mala...Continue Reading

Citations

Jan 1, 1997·Transactions of the Royal Society of Tropical Medicine and Hygiene·P ImbertD Candito
Dec 24, 2004·Antimicrobial Agents and Chemotherapy·Olakunle O KassimVictor R Gordeuk
Mar 24, 2006·Tropical Medicine & International Health : TM & IH·Michael KiharaCharles R J C Newton
Feb 5, 2004·Current Treatment Options in Neurology·Gretchen L. Birbeck
Oct 5, 2002·Clinical Microbiology Reviews·Richard Carter, Kamini N Mendis
Oct 3, 2013·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Macpherson Mallewa, Gretchen L Birbeck
Jul 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·A H MuntendamM B van Hensbroek
Aug 25, 2011·Neurocritical Care·Farrah J Mateen
Mar 14, 2020·The Pediatric Infectious Disease Journal·Samuel KampondeniMichael J Potchen
Oct 30, 2020·Child Neurology Open·Adoukonou ThierryAgossou Joseph
Oct 26, 2007·Malaria Journal·Beatrice NamutangulaJames K Tumwine
May 2, 2007·Malaria Journal·Patrick GérardinPatrick Imbert

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