Mortality and survival in systemic sclerosis: a review of recent literature

Current Opinion in Rheumatology
Dilli R Poudel, Chris T Derk

Abstract

Systemic sclerosis is a debilitating rheumatic disease with high morbidity and mortality. This review attempts to provide the most recent update on mortality and survival and their determinants in systemic sclerosis (SSc). SSc remains an uncommon rheumatic disease with high mortality. There have been attempts to devise more comprehensive but simpler scoring systems to prognosticate survival in SSc, which will influence triaging of patients and guide the utilization of aggressive treatment strategies. Updated literature review on mortality and survival in SSc has confirmed its high-case fatality but a slowly improving survival profile over time. It identifies some gaps in knowledge, especially in regards to ethnic differences.

References

Mar 13, 2002·Medicine·Clodoveo FerriUNKNOWN Systemic Sclerosis Study Group of the Italian Society of Rheumatology (SIR-GSSSc)
Jan 11, 2005·The American Journal of Medicine·John P A IoannidisHaralampos M Moutsopoulos
Jul 3, 2013·Clinical Rheumatology·Gemma StricklandNeil McHugh
Jan 21, 2014·Current Opinion in Rheumatology·Mandana Nikpour, Murray Baron
Mar 5, 2014·Arthritis & Rheumatology·Svetlana I NihtyanovaChristopher P Denton
Jun 17, 2014·Seminars in Arthritis and Rheumatism·Manuel Rubio-RivasVicent Fonollosa
Sep 20, 2016·Nature Reviews. Nephrology·Thasia G WoodworthPhilip Clements
Dec 29, 2016·Arthritis & Rheumatology·Yanjie HaoUNKNOWN Australian Scleroderma Interest Group
Apr 18, 2017·Lancet·Christopher P Denton, Dinesh Khanna
May 31, 2017·Rheumatology International·María Pilar Cruz-DomínguezLuis J Jara
Jun 6, 2017·International Journal of Rheumatic Diseases·Clement OoiDouglas White
Aug 25, 2017·Annals of the Rheumatic Diseases·Muriel ElhaiUNKNOWN EUSTAR group
Oct 12, 2017·Clinical Rheumatology·Thais Rohde PavanRicardo Machado Xavier
Oct 24, 2017·Reumatologia·Saeedeh Shenavandeh, Razieh Naseri

❮ Previous
Next ❯

Citations

Mar 5, 2019·Heart Failure Reviews·Sophie I MavrogeniGenovefa Kolovou
Nov 22, 2019·Current Treatment Options in Rheumatology·Jessica Zhu, Tracy Frech
Oct 1, 2019·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Hoda KavosiZahra Tamartash
Jul 17, 2019·Arthritis Care & Research·Daniel SumptonAllison Tong
Oct 2, 2020·Current Opinion in Rheumatology·Kathleen Morrisroe, Mandana Nikpour
Feb 16, 2021·Rheumatology·Anna-Maria Hoffmann-VoldWim A Wuyts
Jun 26, 2021·Scandinavian Journal of Rheumatology·C-Y LinC-Y Hsu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
Osamu Ishikawa, Kazunori Ohnishi
Seminars in Arthritis and Rheumatism
Hélène ChifflotJean Sibilia
The Journal of Rheumatology
Melissa CaronCanadian Scleroderma Research Group
© 2022 Meta ULC. All rights reserved