Mortality and use of psychotropic medication in sleep apnoea patients: a population-wide register-based study

Sleep Medicine
Poul JennumJakob Kjellberg

Abstract

This study aimed to evaluate all-cause mortality in relation to the use of benzodiazepines, antidepressants and antipsychotics in obstructive sleep apnoea (OSA) patients and matched controls. Patients with a diagnosis of OSA and no pre-index use of psychotropic medication (n = 38,735) were compared with control subjects (n = 75,941) matched by age, gender, marital status and community location. National register data were used to obtain information on diagnoses (the Danish National Patient Registry), mortality (the Central Person Register) and psychotropic medication use (the Danish Register on Medicinal Product Statistics). All-cause mortality was higher in patients with OSA than in control subjects. Mortality hazard ratios were higher for OSA patients and controls who were prescribed serotonergic antidepressant drugs (HR = 1.808, SD = 0.015, p = 0.001 in OSA patients; HR = 2.607, SD = 0.158, p < 0.001 in controls), tricyclic antidepressants (HR = 1.846, SD = 0.166, p < 0.001; HR = 2.087, SD = 0.172, p < 0.001), benzodiazepines (HR = 2.590, SD = 0.040, p < 0.001); (HR = 3.705, SD = 0.085, p < 0.001), benzodiazepine-like drugs (HR = 1.980, SD = 0.087, p < 0.001; HR = 2.227, SD = 0.083, p < 0.001), first-generation antipsychotic...Continue Reading

Citations

Apr 23, 2020·European Journal of Dental Education : Official Journal of the Association for Dental Education in Europe·Alberto Herrero BabiloniGilles J Lavigne
Jan 23, 2019·Frontiers in Pharmacology·Sheng-Huei WangChia-Hung Kao
Jun 11, 2021·BMJ Open Respiratory Research·Emily S HeilbrunnAnna E Ssentongo

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