Mortality associated with bloodstream infection after coronary artery bypass surgery

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Margaret A OlsenV J Fraser

Abstract

Mortality attributable to bloodstream infection (BSI) is still controversial. We studied the impact of BSI on mortality after coronary artery bypass surgery, including the specific impact of different etiologic organisms. Our cohort consisted of 4515 patients who underwent coronary artery bypass procedures at a university hospital from 1996 through 2004. We used Society of Thoracic Surgery data supplemented with laboratory and infection control data. Mortality dates were identified using Society of Thoracic Surgery data and the Social Security Death Index. BSI within 90 days after surgery was defined by a positive blood culture result. Cox proportional hazards and propensity score models were used to analyze the association between BSI and mortality. Patients with BSI had a 4.2-fold increased risk of death (95% confidence interval [CI], 3.0-5.9) 2-90 days after coronary artery bypass surgery, compared with uninfected patients. The risk of death was higher among patients with BSI due to gram-negative bacteria (hazard ratio [HR], 6.8; 95% CI, 3.9-12.0) and BSI due to Staphylococcus aureus (HR, 7.2; 95% CI, 3.3-15.7) and lowest among patients with BSI caused by gram-positive bacteria other than S. aureus (HR, 2.2; 95% CI, 1.1-4.6)...Continue Reading

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Citations

Sep 28, 2014·The Journal of Thoracic and Cardiovascular Surgery·Marta KelavaColleen G Koch
Jul 6, 2014·Critical Care Clinics·Howard NearmanNicholas Pesa
Feb 6, 2013·The Annals of Thoracic Surgery·Matteo TrezziColleen G Koch
Jul 12, 2018·Seminars in Cardiothoracic and Vascular Anesthesia·Sergey KaramnovRichard D Urman

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