PMID: 8594267Mar 6, 1996Paper

Mortality associated with low plasma concentration of beta carotene and the effect of oral supplementation

JAMA : the Journal of the American Medical Association
E R GreenbergR W Haile

Abstract

To examine the relationship between beta carotene plasma concentration and beta carotene supplementation and risk of death from major disease causes. Cohort study of plasma concentrations; randomized, controlled clinical trial of supplementation. Medical school-affiliated dermatology practices. A total of 1188 men and 532 women with mean age of 63.2 years, who had enrolled in a randomized clinical trial of beta carotene supplementation to prevent nonmelanoma skin cancer. Oral beta carotene, 50 mg per day for a median of 4.3 years. All-cause mortality and mortality from cardiovascular disease and cancer. During a median follow-up period of 8.2 years, there were 285 deaths. Persons whose initial plasma beta carotene concentrations were in the highest quartile (>0.52 micromol/L [27.7 microg/dL]) had a lower risk of death from all causes (adjusted relative rate [RR], 0.52; 95% confidence interval [CI] 0.44 to 0.87) and from cardiovascular diseases (adjusted RR, 0.57; 95% CI, 0.34 to 0.95) compared with persons with initial concentrations in the lowest quartile (<0.21 micromol/L [11.2 microg/dL]). Patients randomly assigned to beta carotene supplementation showed no reduction in relative mortality rates from all causes (adjusted RR,...Continue Reading

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