Mortality association between obesity and pneumonia using a dual restricted cohort model.

Obesity Research & Clinical Practice
Hao WangDahlia Hassani

Abstract

An obesity survival paradox has been reported among obese patients with pneumonia. To determine the impact of obesity on pneumonia outcomes and analyze the correlation between in-hospital all-cause mortality and obesity among patients with pneumonia. The United States Nationwide Readmissions Database (NRD) was retrospectively analyzed for patients with pneumonia from 2013 to 2014. We used a step-wise restricted and propensity score matching cohort model (dual model) to compare mortality rates and other outcomes among pneumonia patients based on BMI. Mortality was calculated by a Cox proportional hazard model, adjusted for potential confounders with propensity score matched analysis. A total of 70,886,775 patients were registered in NRD during the study period. Of these, 7,786,913 patients (11.0%) were considered obese and 1,652,456 patients (2.3%) were admitted to the hospital with pneumonia. Based on the step-wise restricted cohort model, the hazard ratio comparing the mortality rates among obese pneumonia patients to mortality rates among normal BMI pneumonia patients was 0.75 (95% CI 0.60-0.94). The propensity score matched analysis estimated a hazard rate of 0.84 (95% CI 0.79-0.90) and the hazard ratio estimated from the du...Continue Reading

References

Dec 18, 2001·Chest·A El-SolhJ Davies
Sep 27, 2006·Journal of the American College of Surgeons·David J CieslaAngela Sauaia
Jan 31, 2007·Respiratory Research·Mark D EisnerCarlos Iribarren
Apr 9, 2008·Respiratory Research·Bharat ThyagarajanO Dale Williams
Jul 1, 2008·Thorax·K M McCleanJ S Elborn
Jan 21, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·E HanJ Stevens
Nov 21, 2009·International Journal of Epidemiology·Stephen R ColeCharles Poole
Mar 31, 2010·The European Respiratory Journal·J B KornumK Overvad
Nov 26, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Vicente F Corrales-MedinaDaniel M Musher
Mar 20, 2012·American Journal of Respiratory Cell and Molecular Biology·Lauren L KordonowyBenjamin T Suratt
May 2, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R Huttunen, J Syrjänen
Sep 12, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S KahlonS R Majumdar
Dec 12, 2012·The European Respiratory Journal·Anika SinganayagamJames D Chalmers
Jan 8, 2013·The Medical Clinics of North America·Christine Maric-Bilkan
May 9, 2013·Contributions to Nephrology·Ankur JindalJames R Sowers
Jun 27, 2013·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·D T PhungC Chu
Oct 1, 2013·Obesity·Deirdre K Tobias, Frank B Hu
Oct 4, 2013·Critical Care : the Official Journal of the Critical Care Forum·Tsuyoshi HamadaKazuhiko Koike
Nov 19, 2013·Tropical Medicine & International Health : TM & IH·Susan P Fisher-HochJoseph B McCormick
Apr 12, 2014·BMC Medicine·Wei NieQingyu Xiu
Jul 10, 2014·JAMA : the Journal of the American Medical Association·Cynthia L OgdenKatherine M Flegal
Nov 8, 2014·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Stephan WardellJohn Kilpatrick Reid
Mar 15, 2015·Circulation Research·John E HallMichael E Hall
Jul 19, 2015·European Journal of Epidemiology·Hailey R Banack, Jay S Kaufman
Apr 15, 2016·Epidemiology·Matthew SperrinIain Buchan
Apr 30, 2016·American Journal of Respiratory Cell and Molecular Biology·Niki D J UbagsBenjamin T Suratt
Jun 9, 2016·JAMA : the Journal of the American Medical Association·Katherine M FlegalCynthia L Ogden
Jul 7, 2016·The American Journal of Cardiology·Tanush GuptaJulio A Panza
Apr 6, 2017·European Journal of Clinical Investigation·Katherine M FlegalSang-Wook Yi
May 19, 2017·The Journal of Infectious Diseases·Anna M BramleyUNKNOWN Centers for Disease Control and Prevention Etiology of Pneumonia in the Community (EPIC) Study Team
Mar 24, 2018·Obesity·Katherine M Flegal, John P A Ioannidis
Mar 31, 2018·BMJ : British Medical Journal·Peymane AdabPeter H Whincup
Oct 23, 2018·The New England Journal of Medicine·UNKNOWN TARGET Investigators, for the ANZICS Clinical Trials GroupPaul Young
Jul 6, 2019·Frontiers in Immunology·Lígia de A MaiaPatricia R M Rocco

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