Mortality following myocardial infarction among HIV-infected persons: the Center for AIDS Research Network Of Integrated Clinical Systems (CNICS).

BMC Medicine
Matthew J FeinsteinHeidi M Crane

Abstract

Persons with human immunodeficiency virus (HIV) have higher risks for myocardial infarction (MI) than the general population. This is driven in part by higher type 2 MI (T2MI, due to coronary supply-demand mismatch) rates among persons with HIV (PWH). In the general population, T2MI has higher mortality than type 1 MI (T1MI, spontaneous and generally due to plaque rupture and thrombosis). PWH have a greater burden of comorbidities and may therefore have an even greater excess risk for complication and death in the setting of T2MI. However, mortality patterns after T1MI and T2MI in HIV are unknown. We analyzed mortality after MI among PWH enrolled in the multicenter, US-based Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) cohort (N = 28,186). Incident MIs occurring between January 1, 1996, and December 31, 2014, were centrally adjudicated and classified as T1MI or T2MI. We first compared mortality following T1MI vs. T2MI among PWH. Cox survival analyses and Bayesian model averaging were then used to evaluate pre-MI covariates associated with mortality following T1MI and T2MI. Among the 596 out of 28,186 PWH who experienced MI (2.1%; 293 T1MI and 303 T2MI), mortality rates were significantly greater afte...Continue Reading

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Citations

Aug 28, 2020·Journal of the American Heart Association·Franck BoccaraUNKNOWN PACS‐HIV (Prognosis of Acute Coronary Syndrome in HIV‐Infected Patients) Investigators †
Aug 28, 2020·Journal of the American Heart Association·Sebhat Erqou, Maria C Rodriguez-Barradas
Nov 24, 2020·European Heart Journal. Quality of Care & Clinical Outcomes·Monica M ParksPriscilla Y Hsue
Jan 13, 2021·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Heidi M CraneUNKNOWN Centers for AIDS Research Network of Clinical Information Systems
Mar 7, 2021·Journal of Clinical Medicine·Julia Portilla-TamaritJoaquín Portilla
Apr 13, 2021·Current Opinion in HIV and AIDS·Matthew S Durstenfeld, Priscilla Y Hsue
Mar 31, 2021·Sleep·Michael J LeoneM Brandon Westover

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Methods Mentioned

BETA
coronary artery bypass

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