PMID: 15250654Jul 15, 2004Paper

Mortality from chronic obstructive pulmonary disease and pleural mesothelioma in an area contaminated by natural fiber (fluoro-edenite)

Scandinavian Journal of Work, Environment & Health
Annibale BiggeriPietro Comba

Abstract

The purpose of the present study was to investigate the association between mortality from chronic obstructive pulmonary disease (COPD) and exposure to fluoro-edenite, a newly discovered amphibolic fiber found in Biancavilla (Sicily), a municipality on the slope of the Etna volcano, where a high mortality from malignant mesothelioma had been previously observed. Thirty-six municipalities located in the volcanic area of mount Etna were selected for study. An ecological regression model was applied with mortality from COPD as the dependent variable, mortality from mesothelioma as a proxy for exposure to fluoro-edenite, and lung cancer mortality, an urban-rural index, a deprivation index and an aging index as the predictors of COPD mortality. For each municipality, risk classes were determined for the continuous variables with the use of a finite mixture model. A significant association was found between COPD mortality and pleural neoplasm mortality among the women in this study. The association was less consistent for the men. Despite the limitations of this ecological study, the results cohere with the results of toxicologic and observational studies and suggest an etiologic role for fluoro-edenite in nonmalignant respiratory di...Continue Reading

Citations

Jun 20, 2006·Environmental Health : a Global Access Science Source·Maria Grazia PutzuPietro Comba
Jul 3, 2015·Oncology Letters·Venerando RapisardaMargherita Ferrante
Nov 23, 2006·Annals of the New York Academy of Sciences·Caterina BrunoAmerigo Zona
Feb 17, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·S TravaglioneC Fiorentini
May 30, 2016·Environmental Research·Caterina LeddaVenerando Rapisarda
Oct 6, 2016·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Pascal AndujarDidier Jean
Apr 11, 2017·Environmental Research·Venerando RapisardaCarla Loreto
Jan 1, 2009·Environmental Health Insights·Natalie Hemsing, Lorraine Greaves
Mar 25, 2017·Molecular Medicine Reports·Caterina LeddaCarla Loreto

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