PMID: 20101380Jan 27, 2010Paper

Mortality from circulatory system diseases and low-level radon exposure in the French cohort study of uranium miners, 1946-1999

Scandinavian Journal of Work, Environment & Health
Simon NusinoviciD Laurier

Abstract

The few studies examining the risk of circulatory system diseases (CSD) associated with ionizing radiation have reported inconsistent results. Radon, a known pulmonary carcinogen, emits ionizing radiation. The aim of this study was to examine CSD mortality in a French cohort of uranium miners and evaluate the plausibility of an association with radon exposure. The cohort included men employed as uranium miners for >/=1 year between 1946-1990. We obtained vital status and cause of death from national registers and reconstructed radon exposure for each year. Exposure--risk relations were estimated with a linear excess relative risk (ERR) model using a 5-year lag time. The cohort comprised 5086 miners, followed up for a mean duration of 30.1 years. The average cumulative exposure of the radon-exposed miners was 36.6 working level months (WLM). A total of 1411 deaths were observed, including 319 deaths due to CSD. No excess risk was found for this overall cause of death. A significant positive trend was observed between deaths from cerebrovascular diseases (CeVD) and cumulative radon exposure, together with a significant ERR per 100 WLM [ERR per 100 WLM 0.49, 95% confidence interval (95% CI) 0.07-1.23)]. Hard physical activity was ...Continue Reading

Citations

Apr 27, 2012·Journal of Exposure Science & Environmental Epidemiology·Jeri L AndersonChih-Yu Tseng
Oct 10, 2012·American Journal of Epidemiology·Michelle C TurnerMichael J Thun
Dec 3, 2014·Revue D'épidémiologie Et De Santé Publique·I Guseva CanuD Laurier
Nov 21, 2014·International Archives of Occupational and Environmental Health·E RageD Laurier
Jun 5, 2015·Mutation Research. Reviews in Mutation Research·Michaela KreuzerMaria Gomolka
Dec 7, 2010·Radiation Research·Rachel S D LaneLydia B Zablotska
Oct 20, 2018·Journal of Occupational and Environmental Medicine·Vanessa J M al RashidaAkshay Sood
Sep 25, 2017·International Archives of Occupational and Environmental Health·Lydia B ZablotskaMichaela Kreuzer
Jan 3, 2019·Journal of Occupational and Environmental Medicine·Vanessa J M Al RashidaAkshay Sood

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