Mortality from peptic ulcer bleeding: the impact of comorbidity and the use of drugs that promote bleeding

Alimentary Pharmacology & Therapeutics
K AhsbergC Staël von Holstein

Abstract

Use of drugs promoting peptic ulcer bleed has increased several folds. To make a time-trend analysis of peptic ulcer bleed patients and evaluate the impact of age, gender, comorbidity and use of drugs promoting peptic ulcer bleed on outcome. Retrospective review of hospitalizations for peptic ulcer bleed at Lund University Hospital during 1984, 1994 and 2004. Univariate analyses between years and multivariable logistic regression for risk factors of fatal outcome. Incidence decreased from 62.0 to 32.1 per 100 000 inhabitants between 1984 and 2004. Mortality rates were stable. Median age (70–77 years; P = 0.001), number of comorbidities (mean +/- s.d.: 0.88 +/- 0.96 to 1.16 +/- 0.77; P = 0.021), use of aspirin (16–57%; P < 0.001) and warfarin (5–17%; P = 0.02) increased. Pharmacological and endoscopic therapy improved. Age above 65 years (OR: 1.11, 95% CI: 1.02–1.23) and number of comorbidities (OR: 6.00, 95% CI: 2.56–17.4) were independent risk factors for in-hospital mortality. Bleeding promoting drugs did not influence outcome negatively. Aspirin decreased the risk of fatal outcome (OR: 0.12, 95% CI: 0.012–0.67). Incidence of peptic ulcer bleed decreased despite higher prescription rates of bleeding promoting drugs. The in-ho...Continue Reading

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Citations

Apr 1, 2011·Internal and Emergency Medicine·Angelo ZulloSergio Morini
Jan 28, 2014·Alimentary Pharmacology & Therapeutics·H MalmiM A Färkkilä
Jan 16, 2015·Alimentary Pharmacology & Therapeutics·L Holland-BillH T Sørensen
Nov 2, 2014·The International Journal of Pharmacy Practice·Brett V MacFarlaneAndrew Matthews
Jun 1, 2016·Alimentary Pharmacology & Therapeutics·H MalmiM A Färkkilä
Nov 9, 2016·BMC Medicine·Carmelo ScarpignatoUNKNOWN Italian Society of Pharmacology, the Italian Association of Hospital Gastroenterologists, and the Italian Federation of Gene
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Feb 6, 2013·The American Journal of Gastroenterology·Grigorios I LeontiadisColin W Howden
May 21, 2018·Journal of the Chinese Medical Association : JCMA·Xi-Hsuan LinFa-Yauh Lee
Jun 7, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Chih-Chia LiangChiu-Ching Huang
Sep 1, 2017·European Journal of Gastroenterology & Hepatology·Hanna MalmiMartti A Färkkilä
Nov 18, 2020·Current Treatment Options in Gastroenterology·Takeshi Kanno, Paul Moayyedi
May 26, 2021·Journal of Gastroenterology and Hepatology·Hong Jae JeonHyun Yong Jeong

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