Mortality hazard and survival after tuberculosis treatment

American Journal of Public Health
Thaddeus L MillerStephen E Weis

Abstract

We compared mortality among tuberculosis (TB) survivors and a similar population. We used local health authority records from 3 US sites to identify 3853 persons who completed adequate treatment of TB and 7282 individuals diagnosed with latent TB infection 1993 to 2002. We then retrospectively observed mortality after 6 to 16 years of observation. We ascertained vital status as of December 31, 2008, using the Centers for Disease Control and Prevention's National Death Index. We analyzed mortality rates, hazards, and associations using Cox regression. We traced 11 135 individuals over 119 772 person-years of observation. We found more all-cause deaths (20.7% vs 3.1%) among posttreatment TB patients than among the comparison group, an adjusted average excess of 7.6 deaths per 1000 person-years (8.8 vs 1.2; P < .001). Mortality among posttreatment TB patients varied with observable factors such as race, site of disease, HIV status, and birth country. Fully treated TB is still associated with substantial mortality risk. Cure as currently understood may be insufficient protection against TB-associated mortality in the years after treatment, and TB prevention may be a valuable opportunity to modify this risk.

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Citations

May 18, 2019·BMC Infectious Diseases·Rawabi AljadaniHamdan Al-Jahdali
Sep 24, 2020·JAMA Network Open·Christian Lee-RodriguezJacek Skarbinski
Sep 12, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G J FoxG B Marks
Mar 1, 2018·Annals of the American Thoracic Society·Suzanne F BeaversUNKNOWN Tuberculosis Epidemiologic Studies Consortium
Jan 2, 2020·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·Angélica MedinaEdith Alarcón
Oct 20, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Serena P KoenigJean W Pape
Jan 8, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Yen Jun WongShaun Wen Huey Lee
Jul 9, 2021·Journal of the International AIDS Society·Yvetot JosephSerena P Koenig
Jun 11, 2021·Tropical Medicine & International Health : TM & IH·V G RaoJyothi Bhat

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