Mortality in Asthma-Chronic Obstructive Pulmonary Disease Overlap in the United States

Southern Medical Journal
Suchit Kumbhare, Charlie Strange

Abstract

Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is recognized increasingly as a distinct clinical entity and is associated with higher comorbidities compared with patients with asthma and COPD alone. Little is known about the leading causes of death related to ACO in the US general population, however. Our aim was to define the causes of mortality among patients with ACO compared with asthma and COPD in the US population. We examined questions using the National Health and Nutrition Examination Survey III database linked to the National Death Index. The data from 4434 participants were stratified into 4 groups, those with asthma, COPD, ACO, and those without any obstructive lung disease. We examined baseline demographics and used multivariate logistic regression to model the impact of demographics, smoking, and self-reported, physician-diagnosed lung disease on mortality generating odds ratios (ORs) and confidence intervals (CIs). Among 4434 participants, 120 (2.7%), 340 (7.6%), and 126 (2.8%) participants self-reported diagnoses of asthma, COPD, and ACO syndrome, respectively. Patients with COPD were older (69.7 ± 10.9 years) than other groups. Cardiovascular disease, malignancy, and chronic lower respiratory...Continue Reading

References

May 8, 2002·American Journal of Epidemiology·R Graham BarrCarlos A Camargo
Mar 15, 2008·Chest·Fadia T ShayaSteven M Scharf
Apr 1, 2009·The American Journal of Medicine·R Graham BarrGerard M Turino
Apr 18, 2009·The American Journal of Emergency Medicine·Michael S RadeosCarlos A Camargo
May 8, 2009·Current Medical Research and Opinion·Christopher M BlanchetteAnand A Dalal
Feb 18, 2011·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Paula KauppiTarja Laitinen
Oct 5, 2011·Allergologia et immunopathologia·Ö AydinY S Demirel
Dec 11, 2013·BMC Pulmonary Medicine·Jose Gregorio Soto-CamposUNKNOWN Grupo Emergente de Asma (GEA) del Área de Asma de la SEPAR
May 31, 2014·The European Respiratory Journal·Megan HardinCraig P Hersh
Jun 25, 2014·Respiratory Medicine·M MilaneseUNKNOWN ELSA Study Group
Feb 13, 2015·Chest·David M ManninoKangho Suh
Mar 15, 2016·Annals of the American Thoracic Society·Suchit KumbhareCharlie Strange

❮ Previous
Next ❯

Citations

Sep 16, 2020·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Asieh HaghighiRafael E de la Hoz
Jun 19, 2021·The American Journal of Emergency Medicine·Michael W TsoulisAdam J Singer
Jun 26, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Evgeni MekovMarc Miravitlles

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.