Mortality in COPD patients according to clinical phenotypes

International Journal of Chronic Obstructive Pulmonary Disease
Rafael GolpeLuis A Pérez de Llano

Abstract

Grouping COPD subjects into clinical phenotypes might be useful for the management of the disease, but the clinical implications of such classification are still not totally clear, especially regarding prognosis. The primary objective of this study was to assess whether the mortality rates were different between four predefined clinical phenotypes. This is a retrospective, observational study carried out at the COPD clinic of a University Hospital. A total of 891 COPD patients were classified, according to the Spanish COPD guidelines, into the following four phenotypes: asthma-COPD overlap (ACO; 75 subjects), nonexacerbator (NONEX; 531 subjects), exacerbator with chronic bronchitis (EXCB; 194 subjects), and exacerbator with emphysema (EXEMPH; 91 subjects). We compared the mortality outcomes between the phenotypes. After a follow-up of 48.4±25.2 months, there were 194 deaths (21.8%). There were significant differences in all-cause mortality between phenotypes. The ACO phenotype had the best long-term prognosis, whereas EXEMPH had the highest risk of death. NONEX and EXCB mortality figures were in between the other two groups. We also found some differences in the causes of death, and patients with EXEMPH were at a higher risk of...Continue Reading

Citations

Jul 23, 2020·European Journal of Clinical Investigation·Vincenzo RussoGerardo Nigro
Sep 22, 2020·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Kristian BratVladimir Koblizek
May 7, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Kristian BratVladimir Koblizek
Jun 19, 2021·The American Journal of Emergency Medicine·Michael W TsoulisAdam J Singer
Jun 26, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Evgeni MekovMarc Miravitlles

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